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Rabbit Anti-NELFCD Recombinant Antibody (CBYJT-1494) (CBMAB-T0525-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Horse
Clone
CBYJT-1494
Antibody Isotype
IgG
Application
WB, IP, ChIP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Negative Elongation Factor Complex Member C/D
Introduction
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. NELFCD is an necessary part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.
Entrez Gene ID
Human51497
Mouse57314
Rat679203
Monkey696053
Hamster101836210
Cattle514958
Dog477276
Horse100056555
UniProt ID
HumanQ8IXH7
MouseQ922L6
RatM0RAI9
MonkeyF6S8Y6
HamsterA0A1U7QL59
CattleF1MW69
DogF1PIH1
HorseF6WUM6
Alternative Names
Negative Elongation Factor Complex Member C/D; Trihydrophobin 1; TH1-Like Protein; NELF-C/D; TH1L; TH1; Negative Elongation Factor Proteins C And D; Negative Elongation Factor C/D
Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062).

The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).

(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Biological Process
Negative regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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