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Rat Anti-NEO1 Recombinant Antibody (CBWJN-1330) (CBMAB-N1971-WJ)

This product is a Rat antibody that recognizes NEO1. The antibody CBWJN-1330 can be used for immunoassay techniques such as: WB.
See all NEO1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJN-1330
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neogenin 1
Introduction
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Entrez Gene ID
18007
UniProt ID
P97798
Alternative Names
Neogenin 1; Immunoglobulin Superfamily DCC Subclass Member 2; IGDCC2; NGN; Immunoglobulin Superfamily, DCC Subclass, Member 2; Neogenin (Chicken) Homolog 1; Neogenin Homolog 1; Neogenin; NTN1R2;
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Biological Process
Axon guidance Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Iron ion homeostasis Source: MGI
Neuron migration Source: GO_Central
Positive regulation of BMP signaling pathway Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 34-1105
Helical: 1106-1126
Cytoplasmic: 1127-1461

Hu, X., Li, L., Li, F., Yang, Y., An, J., Zhou, X., ... & Xu, Y. (2023). Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling. Cell Death Discovery, 9(1), 47.

Zhang, J., Xu, Y., Wei, C., Yin, Z., Pan, W., Zhao, M., ... & Wang, M. (2023). Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling. Cellular and Molecular Life Sciences, 80(11), 324.

Li, N., Liu, H., Xue, Y., Chen, J., Kong, X., & Zhang, Y. (2022). Upregulation of neogenin-1 by a CREB1-BAF47 complex in vascular endothelial cells is implicated in atherogenesis. Frontiers in Cell and Developmental Biology, 10, 803029.

Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., ... & Trumpp, A. (2021). Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. Nature communications, 12(1), 608.

Villanueva, A. A., Sanchez-Gomez, P., Muñoz-Palma, E., Puvogel, S., Casas, B. S., Arriagada, C., ... & Palma, V. (2021). The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation. Cell Adhesion & Migration, 15(1), 58-73.

Ren, X., Yao, L. L., Pan, J. X., Zhang, J. S., Mei, L., Wang, Y. G., & Xiong, W. C. (2021). Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease–like vasculopathy. Neurobiology of Disease, 154, 105339.

Yao, L. L., Hu, J. X., Li, Q., Lee, D., Ren, X., Zhang, J. S., ... & Xiong, W. C. (2020). Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex. The Journal of clinical investigation, 130(12), 6490-6509.

Lin, S., Liu, W., Chen, C. L., Sun, D., Hu, J. X., Li, L., ... & Xiong, W. C. (2020). Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation. Journal of Molecular Cell Biology, 12(1), 17-31.

Gulati, G. S., Zukowska, M., Noh, J. J., Zhang, A., Wesche, D. J., Sinha, R., ... & Szade, K. (2019). Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ mouse long-term hematopoietic stem cells. Proceedings of the National Academy of Sciences, 116(50), 25115-25125.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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