NEO1

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Full Name
Neogenin 1
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Biological Process
Axon guidance Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Iron ion homeostasis Source: MGI
Neuron migration Source: GO_Central
Positive regulation of BMP signaling pathway Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 34-1105
Helical: 1106-1126
Cytoplasmic: 1127-1461
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Anti-NEO1 antibodies

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Rabbit Anti-NEO1 Recombinant Antibody (D7M8E) (CBMAB-CP1674-LY)

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Target: NEO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D7M8E
Application*: WB, IP
Datasheet SDS

Rat Anti-NEO1 Recombinant Antibody (CBWJN-0846) (CBMAB-N1977-WJ)

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Target: NEO1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJN-0846
Application*: WB
Datasheet SDS

Mouse Anti-NEO1 Recombinant Antibody (G-7) (CBMAB-N1976-WJ)

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Target: NEO1
Host: Mouse
Specificity: Human, Mouse
Clone: G-7
Application*: WB, IP, IF, E
Datasheet SDS

Rat Anti-NEO1 Recombinant Antibody (CBWJN-0218) (CBMAB-N1972-WJ)

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Target: NEO1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJN-0218
Application*: WB
Datasheet SDS

Rat Anti-NEO1 Recombinant Antibody (CBWJN-1330) (CBMAB-N1971-WJ)

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Target: NEO1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJN-1330
Application*: WB
Datasheet SDS

Mouse Anti-NEO1 Recombinant Antibody (CBWJN-0974) (CBMAB-N0252-WJ)

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Target: NEO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0974
Application*: E
Datasheet SDS

Rabbit Anti-NEO1 Recombinant Antibody (BA0143) (CBMAB-0508CQ)

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Target: NEO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0143
Application*: WB, IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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