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NEO1

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Full Name

Neogenin 1

Function

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

Biological Process

Axon guidance Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Iron ion homeostasis Source: MGI
Neuron migration Source: GO_Central
Positive regulation of BMP signaling pathway Source: InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 34-1105
Helical: 1106-1126
Cytoplasmic: 1127-1461

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Anti-NEO1 antibodies

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Rabbit Anti-NEO1 Recombinant Antibody (D7M8E) (CBMAB-CP1674-LY)

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Target: NEO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D7M8E

Application*: WB, IP

Rat Anti-NEO1 Recombinant Antibody (CBWJN-0846) (CBMAB-N1977-WJ)

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Target: NEO1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBWJN-0846

Application*: WB

Mouse Anti-NEO1 Recombinant Antibody (G-7) (CBMAB-N1976-WJ)

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Target: NEO1

Host: Mouse

Specificity: Human, Mouse

Clone: G-7

Application*: WB, IP, IF, E

Rat Anti-NEO1 Recombinant Antibody (CBWJN-0218) (CBMAB-N1972-WJ)

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Target: NEO1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBWJN-0218

Application*: WB

Rat Anti-NEO1 Recombinant Antibody (CBWJN-1330) (CBMAB-N1971-WJ)

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Target: NEO1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBWJN-1330

Application*: WB

Mouse Anti-NEO1 Recombinant Antibody (CBWJN-0974) (CBMAB-N0252-WJ)

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Target: NEO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0974

Application*: E

Rabbit Anti-NEO1 Recombinant Antibody (BA0143) (CBMAB-0508CQ)

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Target: NEO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: BA0143

Application*: WB, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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