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Mouse Anti-NEU1 Recombinant Antibody (CBWJN-0979) (CBMAB-N0268-WJ)

This product is a Mouse antibody that recognizes NEU1. The antibody CBWJN-0979 can be used for immunoassay techniques such as: WB, IP.
See all NEU1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0979
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuraminidase 1
Introduction
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4758
UniProt ID
Q99519
Alternative Names
Neuraminidase 1; Sialidase 1 (Lysosomal Sialidase); N-Acetyl-Alpha-Neuraminidase 1; Acetylneuraminyl Hydrolase; Lysosomal Sialidase; G9 Sialidase; EC 3.2.1.18;
Function
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Biological Process
Ganglioside catabolic process Source: GO_Central
Oligosaccharide catabolic process Source: UniProtKB
Cellular Location
Lysosome
Lysosome membrane
Lysosome lumen
Plasma membrane
Cell membrane
Other locations
Cytoplasmic vesicle
Note: Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Involvement in disease
Sialidosis (SIALIDOSIS):
Lysosomal storage disease occurring as two types with various manifestations. Type 1 sialidosis (cherry red spot-myoclonus syndrome or normosomatic type) is late-onset and it is characterized by the formation of cherry red macular spots in childhood, progressive debilitating myoclonus, insiduous visual loss and rarely ataxia. The diagnosis can be confirmed by the screening of the urine for sialyloligosaccharides. Type 2 sialidosis (also known as dysmorphic type) occurs as several variants of increasing severity with earlier age of onset. It is characterized by the presence of abnormal somatic features including coarse facies and dysostosis multiplex, vertebral deformities, mental retardation, cherry-red spot/myoclonus, sialuria, cytoplasmic vacuolation of peripheral lymphocytes, bone marrow cells and conjunctival epithelial cells.
PTM
N-glycosylated.
Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.

Chen, Q. Q., Liu, K., Shi, N., Ma, G., Wang, P., Xie, H. M., ... & Zhang, L. (2023). Neuraminidase 1 promotes renal fibrosis development in male mice. Nature Communications, 14(1), 1713.

Toussaint, K., Appert-Collin, A., Morjani, H., Albrecht, C., Sartelet, H., Romier-Crouzet, B., ... & Bennasroune, A. (2022). Neuraminidase-1: a sialidase involved in the development of cancers and metabolic diseases. Cancers, 14(19), 4868.

Wang, Q., Chen, Z., Peng, X., Zheng, Z., Le, A., Guo, J., ... & Zhu, J. (2021). Neuraminidase 1 exacerbating aortic dissection by governing a pro-inflammatory program in macrophages. Frontiers in Cardiovascular Medicine, 8, 788645.

Chen, Q. Q., Ma, G., Liu, J. F., Cai, Y. Y., Zhang, J. Y., Wei, T. T., ... & Qi, L. W. (2021). Neuraminidase 1 is a driver of experimental cardiac hypertrophy. European Heart Journal, 42(36), 3770-3782.

Heimerl, M., Sieve, I., Ricke-Hoch, M., Erschow, S., Battmer, K., Scherr, M., & Hilfiker-Kleiner, D. (2020). Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages. Basic Research in Cardiology, 115, 1-17.

Allendorf, D. H., Franssen, E. H., & Brown, G. C. (2020). Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of toll‐like receptor 4. Journal of Neurochemistry, 155(4), 403-416.

Kong, F., Li, N., Tu, T., Tao, Y., Bi, Y., Yuan, D., ... & Tang, R. (2020). Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis. Laboratory Investigation, 100(12), 1602-1617.

Albrecht, C., Kuznetsov, A. S., Appert-Collin, A., Dhaideh, Z., Callewaert, M., Bershatsky, Y. V., ... & Bennasroune, A. (2020). Transmembrane peptides as a new strategy to inhibit neuraminidase-1 activation. Frontiers in Cell and Developmental Biology, 8, 611121.

Thulasiraman, P., Kerr, K., McAlister, K., Hardisty, S., Wistner, A., & McCullough, I. (2019). Neuraminidase 1 regulates proliferation, apoptosis and the expression of Cadherins in mammary carcinoma cells. Molecular and Cellular Biochemistry, 462, 207-215.

Bennasroune, A., Romier-Crouzet, B., Blaise, S., Laffargue, M., Efremov, R. G., Martiny, L., ... & Duca, L. (2019). Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage. Matrix Biology, 84, 57-67.

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For research use only. Not intended for any clinical use.

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