Mouse Anti-NEURL1 Recombinant Antibody (L26) (CBMAB-N2032-WJ)

Name: Mouse Anti-NEURL1 Recombinant Antibody (L26)
SKU: CBMAB-N2032-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

L26

Application

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuralized E3 Ubiquitin Protein Ligase 1

Introduction

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Entrez Gene ID

9148

UniProt ID

O76050

Alternative Names

Neuralized E3 Ubiquitin Protein Ligase 1; RING-Type E3 Ubiquitin Transferase NEURL1; Neuralized-Like Protein 1A; RING Finger Protein 67; H-Neuralized 1; NEURL; RNF67; E3 Ubiquitin-Protein Ligase NEURL1; Neuralized Homolog (Drosophila); Neuralized (Drosophila)-Like;

Function

Biological Process

Brain development Source: Ensembl
Cellular response to amino acid stimulus Source: UniProtKB
Lactation Source: Ensembl
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of Notch signaling pathway Source: UniProtKB
Nervous system development Source: GO_Central
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of dendritic spine development Source: UniProtKB
Positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Positive regulation of synapse maturation Source: UniProtKB
Protein monoubiquitination Source: UniProtKB
Skeletal muscle tissue development Source: Ensembl
Sperm axoneme assembly Source: Ensembl

Cellular Location

Plasma membrane
Cell membrane
Other locations
perinuclear region
Perikaryon
dendrite
postsynaptic density
Note: Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.

PTM

Myristoylation is a determinant of membrane targeting.

Zhu, J., Li, Y., Zhong, C., Zhu, M., Zheng, Y., Xiong, A., ... & Huang, J. (2023). Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate: Neuritin regulates the activity of the E3 ligase NEURL1. Acta Biochimica et Biophysica Sinica, 55(10), 1650.

Akın, S., Gültekin, F., & Güler, E. M. (2022). The Relationship of Learning and Memory Disfunction with NEURL1 and RGS14 Genes in Patients with Autism Spectrum Disorders.

ECIROGLU, H., Şener, E. F., Öztop, D. B., Özmen, S., Dilek, K. A. A. N., & ÖZKUL, Y. (2022). The relationship of learning and memory disfunction with NEURL1 and RGS14 genes in patients with autism spectrum disorders. Acta Medica Alanya, 6(2), 207-213.

Szirák, K., Soltész, B., Hajas, O., Urbancsek, R., Nagy-Baló, E., Penyige, A., ... & Nagy, B. (2019). PITX2 and NEURL1 SNP polymorphisms in Hungarian atrial fibrillation patients determined by quantitative real-time PCR and melting curve analysis. Journal of biotechnology, 299, 44-49.

Taal, K., Tuvikene, J., Rullinkov, G., Piirsoo, M., Sepp, M., Neuman, T., ... & Timmusk, T. (2019). Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A. Scientific Reports, 9(1), 7104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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