NEURL1

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Neuralized E3 Ubiquitin Protein Ligase 1

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Brain development Source: Ensembl
Cellular response to amino acid stimulus Source: UniProtKB
Lactation Source: Ensembl
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of Notch signaling pathway Source: UniProtKB
Nervous system development Source: GO_Central
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of dendritic spine development Source: UniProtKB
Positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Positive regulation of synapse maturation Source: UniProtKB
Protein monoubiquitination Source: UniProtKB
Skeletal muscle tissue development Source: Ensembl
Sperm axoneme assembly Source: Ensembl

Plasma membrane
Cell membrane
Other locations
perinuclear region
Perikaryon
dendrite
postsynaptic density
Note: Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.

Myristoylation is a determinant of membrane targeting.