Mouse Anti-NEUROG1 Recombinant Antibody (15A7) (CBMAB-N2061-WJ)

Name: Mouse Anti-NEUROG1 Recombinant Antibody (15A7)
SKU: CBMAB-N2061-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

15A7

Application

ICC, IHC, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

neurogenin 1

Introduction

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Entrez Gene ID

4762

UniProt ID

Q92886

Alternative Names

Neurogenin 1; Neurogenic Basic-Helix-Loop-Helix Protein; Class A Basic Helix-Loop-Helix Protein 6; Neurogenic Differentiation Factor 3; Neurogenic Differentiation 3; NEUROD3; BHLHa6;

Function

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Biological Process

Auditory behavior Source: CAFA
Cell fate commitment Source: Ensembl
Cochlea development Source: CAFA
Cochlea morphogenesis Source: CAFA
Craniofacial suture morphogenesis Source: CAFA
Genitalia development Source: CAFA
Genitalia morphogenesis Source: CAFA
Hard palate morphogenesis Source: CAFA
Inner ear development Source: CAFA
Inner ear morphogenesis Source: CAFA
Learned vocalization behavior Source: CAFA
Mastication Source: CAFA
Negative regulation of relaxation of muscle Source: CAFA
Negative regulation of saliva secretion Source: CAFA
Nervous system development Source: ProtInc
Neuromuscular process controlling balance Source: CAFA
Neuron differentiation Source: GO_Central
Peristalsis Source: CAFA
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of exit from mitosis Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of muscle organ development Source: CAFA
Regulation of transcription by RNA polymerase II Source: GO_Central
Thorax and anterior abdomen determination Source: CAFA
Trigeminal nerve development Source: CAFA
Vestibulocochlear nerve formation Source: CAFA

Cellular Location

Nucleus

Altbürger, C., Rath, M., Armbruster, D., & Driever, W. (2024). Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons. Developmental Biology, 505, 85-98.

Sheth, F., Shah, J., Patel, K., Patel, D., Jain, D., Sheth, J., & Sheth, H. (2023). A novel case of two siblings harbouring homozygous variant in the NEUROG1 gene with autism as an additional phenotype: a case report. BMC neurology, 23(1), 20.

Song, E. C., Park, C., Shin, Y., Kim, W. K., Kim, S. B., & Cho, S. (2023). Neurog1-Derived Peptides RMNE1 and DualPep-Shine Penetrate the Skin and Inhibit Melanin Synthesis by Regulating MITF Transcription. International Journal of Molecular Sciences, 24(7), 6158.

Elliott, K. L., Pavlinkova, G., Chizhikov, V. V., Yamoah, E. N., & Fritzsch, B. (2021). Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development. Faculty Reviews, 10.

Dupont, J., Vieira, J. P., Tavares, A. L. T., Conceição, C. R., Khan, S., Bertoli‐Avella, A. M., & Sousa, A. B. (2021). Adding evidence to the role of NEUROG1 in congenital cranial dysinnervation disorders. Clinical Genetics, 99(4), 588-593.

Otero-Estévez, O., Gallardo-Gomez, M., Páez de la Cadena, M., Rodríguez-Berrocal, F. J., Cubiella, J., Hernandez Ramirez, V., ... & De Chiara, L. (2020). Value of serum NEUROG1 Methylation for the detection of advanced adenomas and colorectal cancer. Diagnostics, 10(7), 437.

Lu, C., Shi, X., Allen, A., Baez-Nieto, D., Nikish, A., Sanjana, N. E., & Pan, J. Q. (2019). Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. The FASEB Journal, 33(4), 5287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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