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Mouse Anti-NEUROG2 Recombinant Antibody (3B2) (CBMAB-N2078-WJ)

This product is a Mouse antibody that recognizes NEUROG2. The antibody 3B2 can be used for immunoassay techniques such as: ELISA, WB.
See all NEUROG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurogenin 2
Introduction
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
Entrez Gene ID
63973
UniProt ID
Q9H2A3
Alternative Names
Neurogenin 2; Class A Basic Helix-Loop-Helix Protein 8; Protein Atonal Homolog 4; BHLHa8; Atoh4; Ngn-2; NGN2; Neurogenin-2; Math4A;
Function
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Biological Process
Neuron differentiation Source: GO_Central
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Noack, F., Vangelisti, S., Raffl, G., Carido, M., Diwakar, J., Chong, F., & Bonev, B. (2022). Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler. Nature Neuroscience, 25(2), 154-167.

Liu, F., Zhang, Y., Chen, F., Yuan, J., Li, S., Han, S., ... & Liu, Y. (2021). Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord. Cell Death & Disease, 12(3), 225.

Kaufman, M. L., Goodson, N. B., Park, K. U., Schwanke, M., Office, E., Schneider, S. R., ... & Brzezinski, J. A. (2021). Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Development, 148(12), dev199399.

Aslanpour, S., Han, S., Schuurmans, C., & Kurrasch, D. M. (2020). Neurog2 acts as a classical proneural gene in the ventromedial hypothalamus and is required for the early phase of neurogenesis. Journal of Neuroscience, 40(18), 3549-3563.

Liu, J. A., Tai, A., Hong, J., Cheung, M. P. L., Sham, M. H., Cheah, K. S., ... & Cheung, M. (2020). Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization. Proceedings of the National Academy of Sciences, 117(8), 4199-4210.

Lu, C., Shi, X., Allen, A., Baez-Nieto, D., Nikish, A., Sanjana, N. E., & Pan, J. Q. (2019). Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. The FASEB Journal, 33(4), 5287.

Liu, Y., & Zhang, Y. (2019). ETV5 is essential for neuronal differentiation of human neural progenitor cells by repressing NEUROG2 expression. Stem cell reviews and reports, 15, 703-716.

Aydin, B., Kakumanu, A., Rossillo, M., Moreno-Estellés, M., Garipler, G., Ringstad, N., ... & Mazzoni, E. O. (2019). Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes. Nature neuroscience, 22(6), 897-908.

Chouchane, M., & Costa, M. R. (2019). Instructing neuronal identity during CNS development and astroglial-lineage reprogramming: Roles of NEUROG2 and ASCL1. Brain research, 1705, 66-74.

Ventéo, S., Desiderio, S., Cabochette, P., Deslys, A., Carroll, P., & Pattyn, A. (2019). Neurog2 deficiency uncovers a critical period of cell fate plasticity and vulnerability among neural-crest-derived somatosensory progenitors. Cell Reports, 29(10), 2953-2960.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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