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NEUROG2 Matched Antibody Pair (793) (APMAB-793LY)

This antibody pair set can be used for detecting and quantifying protein level of human NEUROG2.
See all NEUROG2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-NEUROG2 monoclonal, IgG2a antibody, 100 ug
Detection Antibody
Anti-NEUROG2 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
Alternative Names
Neurogenin 2; Class A Basic Helix-Loop-Helix Protein 8; Protein Atonal Homolog 4; BHLHa8; Atoh4; Ngn-2; NGN2; Neurogenin-2; Math4A;
Entrez Gene ID
63973
UniProt ID
Q9H2A3

Noack, F., Vangelisti, S., Raffl, G., Carido, M., Diwakar, J., Chong, F., & Bonev, B. (2022). Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler. Nature Neuroscience, 25(2), 154-167.

Liu, F., Zhang, Y., Chen, F., Yuan, J., Li, S., Han, S., ... & Liu, Y. (2021). Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord. Cell Death & Disease, 12(3), 225.

Kaufman, M. L., Goodson, N. B., Park, K. U., Schwanke, M., Office, E., Schneider, S. R., ... & Brzezinski, J. A. (2021). Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Development, 148(12), dev199399.

Aslanpour, S., Han, S., Schuurmans, C., & Kurrasch, D. M. (2020). Neurog2 acts as a classical proneural gene in the ventromedial hypothalamus and is required for the early phase of neurogenesis. Journal of Neuroscience, 40(18), 3549-3563.

Liu, J. A., Tai, A., Hong, J., Cheung, M. P. L., Sham, M. H., Cheah, K. S., ... & Cheung, M. (2020). Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization. Proceedings of the National Academy of Sciences, 117(8), 4199-4210.

Lu, C., Shi, X., Allen, A., Baez-Nieto, D., Nikish, A., Sanjana, N. E., & Pan, J. Q. (2019). Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. The FASEB Journal, 33(4), 5287.

Liu, Y., & Zhang, Y. (2019). ETV5 is essential for neuronal differentiation of human neural progenitor cells by repressing NEUROG2 expression. Stem cell reviews and reports, 15, 703-716.

Aydin, B., Kakumanu, A., Rossillo, M., Moreno-Estellés, M., Garipler, G., Ringstad, N., ... & Mazzoni, E. O. (2019). Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes. Nature neuroscience, 22(6), 897-908.

Chouchane, M., & Costa, M. R. (2019). Instructing neuronal identity during CNS development and astroglial-lineage reprogramming: Roles of NEUROG2 and ASCL1. Brain research, 1705, 66-74.

Ventéo, S., Desiderio, S., Cabochette, P., Deslys, A., Carroll, P., & Pattyn, A. (2019). Neurog2 deficiency uncovers a critical period of cell fate plasticity and vulnerability among neural-crest-derived somatosensory progenitors. Cell Reports, 29(10), 2953-2960.

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For research use only. Not intended for any clinical use.

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