Mouse Anti-NFAM1 Recombinant Antibody (2E9) (CBMAB-N2141-WJ)

Name: Mouse Anti-NFAM1 Recombinant Antibody (2E9)
SKU: CBMAB-N2141-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E9

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NFAT activating protein with ITAM motif 1

Introduction

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]

Entrez Gene ID

150372

UniProt ID

Q8NET5

Alternative Names

NFAT Activating Protein With ITAM Motif 1; Calcineurin/NFAT-Activating ITAM-Containing Protein; CNAIP; NFAT-Activating Protein With ITAM Motif 1; NFAT Activation Molecule 1;

Function

May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.

Biological Process

B cell differentiation Source: HGNC-UCL
B cell receptor signaling pathway Source: GO_Central
Inflammatory response Source: HGNC-UCL
Intracellular signal transduction Source: HGNC-UCL
Positive regulation of B cell receptor signaling pathway Source: HGNC-UCL
Positive regulation of cytokine production Source: HGNC-UCL
Positive regulation of DNA-binding transcription factor activity Source: HGNC-UCL
Regulation of B cell differentiation Source: InterPro
Signal transduction Source: HGNC-UCL

Cellular Location

Plasma membrane
Cell membrane
Note: Partially recruited to lipid rafts upon BCR stimulation.

Topology

Extracellular: 43-163
Helical: 164-184
Cytoplasmic: 185-270

PTM

N-glycosylated.

Juchem, K. W., Gounder, A. P., Gao, J. P., Seccareccia, E., Yeddula, N., Huffmaster, N. J., ... & Chanda, S. K. (2022). NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes. Frontiers in Immunology, 12, 773445.

Zhu, J., Chen, Z., Peng, X., Zheng, Z., Le, A., Guo, J., ... & Wang, Q. (2022). Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. Oxidative Medicine and Cellular Longevity, 2022.

Ethiraj, P., Haque, I. A., Alford, A. K., Gou, W., Singh, T., Sambandam, Y., ... & Reddy, S. V. (2021). Inhibition of NFAM1 suppresses phospho‐SAPK/JNK signaling during osteoclast differentiation and bone resorption. Journal of Cellular Biochemistry, 122(10), 1534-1543.

Long, J., Chen, J., Wang, Q., Gao, F., Lian, M., Zhang, P., ... & Zhu, H. (2020). NFAT activating protein with ITAM motif 1 (NFAM1) is upregulated on circulating monocytes in coronary artery disease and potentially correlated with monocyte chemotaxis. Atherosclerosis, 307, 39-51.

Zhu, J., Chen, Z., Wang, Q., Guo, J., Ma, L., Shi, H., ... & Zheng, Z. (2020). Exosome-derived circITGB1 regulates dendritic cell maturation and cardiac inflammation via miR-342-3p/NFAM1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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