NFAM1

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq]

Full Name

NFAT activating protein with ITAM motif 1

Function

May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.

Biological Process

B cell differentiation Source: HGNC-UCL
B cell receptor signaling pathway Source: GO_Central
Inflammatory response Source: HGNC-UCL
Intracellular signal transduction Source: HGNC-UCL
Positive regulation of B cell receptor signaling pathway Source: HGNC-UCL
Positive regulation of cytokine production Source: HGNC-UCL
Positive regulation of DNA-binding transcription factor activity Source: HGNC-UCL
Regulation of B cell differentiation Source: InterPro
Signal transduction Source: HGNC-UCL

Cellular Location

Plasma membrane
Cell membrane
Note: Partially recruited to lipid rafts upon BCR stimulation.

Topology

Extracellular: 43-163
Helical: 164-184
Cytoplasmic: 185-270

PTM

N-glycosylated.