Mouse Anti-NFRKB Recombinant Antibody (CBWJN-1385) (CBMAB-N2319-WJ)

Name: Mouse Anti-NFRKB Recombinant Antibody (CBWJN-1385)
SKU: CBMAB-N2319-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-1385

Application

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nuclear factor related to kappaB binding protein

Introduction

Binds to the DNA consensus sequence 5-GGGGAATCTCC-3.

Entrez Gene ID

4798

UniProt ID

Q6P4R8

Alternative Names

Nuclear Factor Related To KappaB Binding Protein; INO80 Complex Subunit G; DNA-Binding Protein R Kappa B; INO80G; Nuclear Factor Related To Kappa B Binding Protein; Nuclear Factor Related To Kappa-B-Binding Protein; DNA-Binding Protein R Kappa-B;

Function

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
Nucleosome mobilizationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of chromosome organizationManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of DNA strand elongationManual Assertion Based On ExperimentIMP:ComplexPortal

Cellular Location

Nucleus

Peng, Q., Zhou, M., Zuo, S., Liu, Y., Li, X., Yang, Y., ... & He, Q. (2021). Nuclear factor related to kappaB binding protein (NFRKB) is a telomere-associated protein and involved in liver cancer development. DNA and Cell Biology, 40(10), 1298-1307.

Zhang, Z., Hu, X., Kuang, J., Liao, J., & Yuan, Q. (2020). LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5. Cellular & Molecular Biology Letters, 25(1), 1-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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