• Home
  • NGFR
  • Rabbit Anti-NGFR Recombinant Antibody (A1361)

Rabbit Anti-NGFR Recombinant Antibody (A1361) (CBMAB-AP12617LY)

See all NGFR antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
A1361
Application
ICC, IF, IHC, IP, WB
Immunogen
Recombinant protein of human NGFR
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Nerve Growth Factor Receptor
Introduction
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4804
Mouse18053
Rat24596
UniProt ID
HumanP08138
MouseQ9Z0W1
RatP07174
Alternative Names
Nerve Growth Factor Receptor; Low Affinity Neurotrophin Receptor P75NTR; Low-Affinity Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; NGF Receptor; Gp80-LNGFR; TNFRSF16; P75 ICD;
Function
A11050
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Axon guidanceIEA:Ensembl
Cellular glucose homeostasisISS:UniProtKB
Cellular response to amyloid-betaManual Assertion Based On ExperimentIDA:ARUK-UCL
Central nervous system developmentIEA:Ensembl
Circadian regulation of gene expressionISS:UniProtKB
Detection of temperature stimulusIEA:Ensembl
Dorsal aorta developmentIEA:Ensembl
Glucose homeostasisISS:UniProtKB
Hair follicle morphogenesisIEA:Ensembl
Intracellular protein transportISS:UniProtKB
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Negative regulation of hair follicle developmentIEA:Ensembl
Nerve developmentIEA:Ensembl
Neuron apoptotic processManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of odontogenesis of dentin-containing toothIEA:Ensembl
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Perikaryon
Cell projection, growth cone
Cell projection, dendritic spine
Topology
Extracellular: 29-250
Helical: 251-272
Cytoplasmic: 273-427
PTM
N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.

Bruno, F., Abondio, P., Montesanto, A., Luiselli, D., Bruni, A. C., & Maletta, R. (2023). The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. International Journal of Molecular Sciences, 24(4), 3200.

Siddiqui, T., Cosacak, M. I., Popova, S., Bhattarai, P., Yilmaz, E., Lee, A. J., ... & Kizil, C. (2023). Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease. npj Regenerative Medicine, 8(1), 33.

Wu, R., Li, K., Yuan, M., & Luo, K. Q. (2021). Nerve growth factor receptor increases the tumor growth and metastatic potential of triple-negative breast cancer cells. Oncogene, 40(12), 2165-2181.

Castellini, C., Mattioli, S., Dal Bosco, A., Cotozzolo, E., Mancinelli, A. C., Rende, M., ... & Pistilli, A. (2020). Nerve growth factor receptor role on rabbit sperm storage. Theriogenology, 153, 54-61.

Goten, C., Usui, S., Inoue, O., Okada, H., Takashima, S., Sakata, K., ... & Takamura, M. (2020). Nerve growth factor receptor is involved in maintaining homeostasis of pulmonary arterial hypertension. European Heart Journal, 41(Supplement_2), ehaa946-2235.

Faulkner, S., Griffin, N., Rowe, C. W., Jobling, P., Lombard, J. M., Oliveira, S. M., ... & Hondermarck, H. (2020). Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma. FASEB BioAdvances, 2(7), 398.

Jiang, L., Huang, S., Wang, J., Zhang, Y., Xiong, Y., Zeng, S. X., & Lu, H. (2020). Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis. Cell death & disease, 11(7), 550.

Cao, Y., Li, R., Cheng, L., Chen, N., Li, J., & Yu, D. (2019). p75 nerve growth factor receptor as a specific nerve marker in the diagnosis of Perineural Invasion of squamous cell carcinoma. American Journal of Clinical Pathology, 151(6), 574-583.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-NGFR Recombinant Antibody (A1361)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-NGFR Recombinant Antibody (CBWJN-0754) (CAT#: CBMAB-N0360-WJ)

Mouse Anti-NGFR Recombinant Antibody (CBWJN-0015) (CAT#: CBMAB-N2390-WJ)

Mouse Anti-NGFR Recombinant Antibody (BSB-18) (CAT#: CBMAB-N0353-WJ)

Mouse Anti-NGFR Recombinant Antibody (3A12) (CAT#: CBMAB-A5959-LY)

Mouse Anti-NGFR Recombinant Antibody (CBWJC-4252) (CAT#: CBMAB-C5609WJ)

Mouse Anti-NGFR Recombinant Antibody (A1358) (CAT#: CBMAB-AP5080LY)

Mouse Anti-NGFR Recombinant Antibody (CBWJN-0882) (CAT#: CBMAB-N0361-WJ)

Rabbit Anti-NGFR Recombinant Antibody (CBWJN-0810) (CAT#: CBMAB-N2407-WJ)

Mouse Anti-NGFR Recombinant Antibody (2F1C2) (CAT#: CBMAB-N0348-WJ)

Rabbit Anti-NGFR Recombinant Antibody (BA0003) (CAT#: CBMAB-0520CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry