NGFR
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
Full Name
Nerve Growth Factor Receptor
Function
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).
Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181).
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).
Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Axon guidanceIEA:Ensembl
Cellular glucose homeostasisISS:UniProtKB
Cellular response to amyloid-betaManual Assertion Based On ExperimentIDA:ARUK-UCL
Central nervous system developmentIEA:Ensembl
Circadian regulation of gene expressionISS:UniProtKB
Detection of temperature stimulusIEA:Ensembl
Dorsal aorta developmentIEA:Ensembl
Glucose homeostasisISS:UniProtKB
Hair follicle morphogenesisIEA:Ensembl
Intracellular protein transportISS:UniProtKB
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Negative regulation of hair follicle developmentIEA:Ensembl
Nerve developmentIEA:Ensembl
Neuron apoptotic processManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of odontogenesis of dentin-containing toothIEA:Ensembl
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Perikaryon
Cell projection, growth cone
Cell projection, dendritic spine
Topology
Extracellular: 29-250
Helical: 251-272
Cytoplasmic: 273-427
PTM
N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.
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