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Rabbit Anti-NGFR Recombinant Antibody (BA0003) (CBMAB-0520CQ)

This product is a rabbit antibody that recognizes NGFR. The antibody BA0003 can be used for immunoassay techniques such as: FC, IF, IHC-P, IP, WB.
See all NGFR antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0003
Antibody Isotype
IgG
Application
FC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Human p75 NGF Receptor aa 350-450
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nerve Growth Factor Receptor
Introduction
NGFR was considered a unique type of protein. Subsequently, however, a large superfamily of tumor necrosis factor receptors were found to share the overall structure of NGFR (4 extracellular ligand-binding, cysteine-rich repeats, or CRs, and signaling through association with, or disassociation from, cytoplasmic interactors). The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B and apoptosis pathways. Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Entrez Gene ID
Human4804
Mouse18053
Rat24596
UniProt ID
HumanP08138
MouseQ9Z0W1
RatP07174
Alternative Names
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
Function
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).
Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181).
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).
Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Axon guidanceIEA:Ensembl
Cellular glucose homeostasisISS:UniProtKB
Cellular response to amyloid-betaManual Assertion Based On ExperimentIDA:ARUK-UCL
Central nervous system developmentIEA:Ensembl
Circadian regulation of gene expressionISS:UniProtKB
Detection of temperature stimulusIEA:Ensembl
Dorsal aorta developmentIEA:Ensembl
Glucose homeostasisISS:UniProtKB
Hair follicle morphogenesisIEA:Ensembl
Intracellular protein transportISS:UniProtKB
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Negative regulation of hair follicle developmentIEA:Ensembl
Nerve developmentIEA:Ensembl
Neuron apoptotic processManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of odontogenesis of dentin-containing toothIEA:Ensembl
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Perikaryon
Cell projection, growth cone
Cell projection, dendritic spine
Topology
Extracellular: 29-250
Helical: 251-272
Cytoplasmic: 273-427
PTM
N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.

Bruno, F., Abondio, P., Montesanto, A., Luiselli, D., Bruni, A. C., & Maletta, R. (2023). The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. International Journal of Molecular Sciences, 24(4), 3200.

Siddiqui, T., Cosacak, M. I., Popova, S., Bhattarai, P., Yilmaz, E., Lee, A. J., ... & Kizil, C. (2023). Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease. npj Regenerative Medicine, 8(1), 33.

Wu, R., Li, K., Yuan, M., & Luo, K. Q. (2021). Nerve growth factor receptor increases the tumor growth and metastatic potential of triple-negative breast cancer cells. Oncogene, 40(12), 2165-2181.

Castellini, C., Mattioli, S., Dal Bosco, A., Cotozzolo, E., Mancinelli, A. C., Rende, M., ... & Pistilli, A. (2020). Nerve growth factor receptor role on rabbit sperm storage. Theriogenology, 153, 54-61.

Goten, C., Usui, S., Inoue, O., Okada, H., Takashima, S., Sakata, K., ... & Takamura, M. (2020). Nerve growth factor receptor is involved in maintaining homeostasis of pulmonary arterial hypertension. European Heart Journal, 41(Supplement_2), ehaa946-2235.

Faulkner, S., Griffin, N., Rowe, C. W., Jobling, P., Lombard, J. M., Oliveira, S. M., ... & Hondermarck, H. (2020). Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma. FASEB BioAdvances, 2(7), 398.

Jiang, L., Huang, S., Wang, J., Zhang, Y., Xiong, Y., Zeng, S. X., & Lu, H. (2020). Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis. Cell death & disease, 11(7), 550.

Cao, Y., Li, R., Cheng, L., Chen, N., Li, J., & Yu, D. (2019). p75 nerve growth factor receptor as a specific nerve marker in the diagnosis of Perineural Invasion of squamous cell carcinoma. American Journal of Clinical Pathology, 151(6), 574-583.

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For research use only. Not intended for any clinical use.

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