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Rat Anti-NID1 Recombinant Antibody (4A46) (CBMAB-N2452-WJ)

This product is a Rat antibody that recognizes NID1. The antibody 4A46 can be used for immunoassay techniques such as: ICC, IHC, WB.
See all NID1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
4A46
Antibody Isotype
IgG2a
Application
ICC, IHC, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nidogen 1
Introduction
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]
Entrez Gene ID
18073
UniProt ID
P10493
Alternative Names
Nidogen 1; Entactin; NID-1; NID; Nidogen (Enactin); Nidogen-1; Enactin;
Function
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Biological Process
Basement membrane organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Cell-matrix adhesionIEA:Ensembl
Glomerular basement membrane developmentIEA:Ensembl
Positive regulation of cell adhesion1 PublicationIC:ComplexPortal
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of integrin-mediated signaling pathway1 PublicationIC:ComplexPortal
Positive regulation of muscle cell differentiation1 PublicationIC:ComplexPortal
Regulation of basement membrane organization1 PublicationIC:ComplexPortal
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
PTM
N- and O-glycosylated.

Rokavec, M., Jaeckel, S., & Hermeking, H. (2023). Nidogen-1/NID1 Function and Regulation during Progression and Metastasis of Colorectal Cancer. Cancers, 15(22), 5316.

Ijezie, E. C., O'Dowd, J. M., Kuan, M. I., Faeth, A. R., & Fortunato, E. A. (2023). HCMV Infection Reduces Nidogen-1 Expression, Contributing to Impaired Neural Rosette Development in Brain Organoids. Journal of Virology, 97(5), e01718-22.

Bayramoglu, Z., Kılınc, A. N., Omeroglu, E., Yilmaz, F., Bayramoglu, D., Unlu, Y., & Aydin, H. A. (2022). Expression of extracellular matrix proteins nidogen‐1 and legumain in endometrial carcinomas. Journal of Obstetrics and Gynaecology Research, 48(4), 1019-1025.

Zbinden, A., Layland, S. L., Urbanczyk, M., Carvajal Berrio, D. A., Marzi, J., Zauner, M., ... & Schenke‐Layland, K. (2021). Nidogen‐1 mitigates ischemia and promotes tissue survival and regeneration. Advanced Science, 8(4), 2002500.

Jagroop, R., Martin, C. J., & Moorehead, R. A. (2021). Nidogen 1 regulates proliferation and migration/invasion in murine claudin‑low mammary tumor cells. Oncology Letters, 21(1), 1-1.

Zhang, B., Xu, C., Liu, J., Yang, J., Gao, Q., & Ye, F. (2021). Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients. Aging (Albany NY), 13(6), 9085.

Kuan, M. I., Jaeger, H. K., Balemba, O. B., O’Dowd, J. M., Duricka, D., Hannemann, H., ... & Fortunato, E. A. (2021). Human cytomegalovirus interactions with the basement membrane protein nidogen 1. Journal of Virology, 95(3), e01506-20.

Khaerunnisa, S., Pangjaya, L. F., Mazfufah, N. F., Budiman, R. L., & Antarianto, R. D. (2021, March). Nidogen-1 (NID1) as specific ligand in natural killer (NK) cells stimulated from advanced ovarian cancer: Immunotherapy review. In AIP Conference Proceedings (Vol. 2344, No. 1). AIP Publishing.

Jagroop, R. (2019). The Effects of Nidogen-1 on Claudin-Low Mammary Tumor Cells (Doctoral dissertation, University of Guelph).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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