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Rat Anti-NID2 Recombinant Antibody (CBWJN-1405) (CBMAB-N2453-WJ)

This product is a Rat antibody that recognizes NID2. The antibody CBWJN-1405 can be used for immunoassay techniques such as: WB.
See all NID2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJN-1405
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nidogen 2 (osteonidogen)
Introduction
This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
Entrez Gene ID
18074
UniProt ID
O88322
Alternative Names
Nidogen 2; Osteonidogen; NID-2; Nidogen-2;
Function
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
Biological Process
Basement membrane organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
PTM
Highly N- and O-glycosylated.

Sha, Y., Mao, A. Q., Liu, Y. J., Li, J. P., Gong, Y. T., Xiao, D., ... & Shen, H. (2023). Nidogen-2 (NID2) is a Key Factor in Collagen Causing Poor Response to Immunotherapy in Melanoma. Pharmacogenomics and Personalized Medicine, 153-172.

Chettiankandy, T. J., Sachdev, S. S., Khandekar, S. P., Dive, A., Nagpal, D., & Tupkari, J. V. (2022). Role of Nidogen-2 in diagnosis and prognosis of head and neck squamous cell carcinoma: A systematic review. Journal of Oral and Maxillofacial Pathology: JOMFP, 26(3), 382.

Zhang, J. L., Richetti, S., Ramezani, T., Welcker, D., Lütke, S., Pogoda, H. M., ... & Hammerschmidt, M. (2022). Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2. Matrix Biology, 112, 132-154.

Mao, C., Ma, Z., Jia, Y., Li, W., Xie, N., Zhao, G., ... & Kong, W. (2021). Nidogen-2 maintains the contractile phenotype of vascular smooth muscle cells and prevents neointima formation via bridging Jagged1-Notch3 signaling. Circulation, 144(15), 1244-1261.

Srisuttee, R., Arayataweegool, A., Mahattanasakul, P., Tangjaturonrasme, N., Kerekhanjanarong, V., Keelawat, S., ... & Kitkumthorn, N. (2020). Evaluation of NID2 promoter methylation for screening of Oral squamous cell carcinoma. BMC cancer, 20(1), 1-9.

Yu, Z. H., Wang, Y. M., Jiang, Y. Z., Ma, S. J., Zhong, Q., Wan, Y. Y., & Wang, X. W. (2019). NID2 can serve as a potential prognosis prediction biomarker and promotes the invasion and migration of gastric cancer. Pathology-Research and Practice, 215(10), 152553.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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