NID2

Basement membranes, which are composed of type IV collagens (see MIM 120130), laminins (see LAMC1; MIM 150290), perlecan (HSPG2; MIM 142461), and nidogen (see NID1; MIM 131390), are thin pericellular protein matrices that control a large number of cellular activities, including adhesion, migration, differentiation, gene expression, and apoptosis.[supplied by OMIM

Full Name

nidogen 2 (osteonidogen)

Function

Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.

Biological Process

Basement membrane organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane

PTM

Highly N- and O-glycosylated.

Anti-NID2 antibodies

Rat Anti-NID2 Recombinant Antibody (JF6) (CBMAB-N2456-WJ)

Datasheet

SDS

Target: NID2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: JF6

Application*: WB, E, FN

Mouse Anti-NID2 Recombinant Antibody (4G8) (CBMAB-N2454-WJ)

Datasheet

SDS

Target: NID2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4G8

Application*: E, WB

Rat Anti-NID2 Recombinant Antibody (CBWJN-1405) (CBMAB-N2453-WJ)

Datasheet

SDS

Target: NID2

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBWJN-1405

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)