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NID2

Basement membranes, which are composed of type IV collagens (see MIM 120130), laminins (see LAMC1; MIM 150290), perlecan (HSPG2; MIM 142461), and nidogen (see NID1; MIM 131390), are thin pericellular protein matrices that control a large number of cellular activities, including adhesion, migration, differentiation, gene expression, and apoptosis.[supplied by OMIM

Full Name

nidogen 2 (osteonidogen)

Function

Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.

Biological Process

Basement membrane organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane

PTM

Highly N- and O-glycosylated.

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Anti-NID2 antibodies

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Rat Anti-NID2 Recombinant Antibody (JF6) (CBMAB-N2456-WJ)

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Target: NID2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: JF6

Application*: WB, E, FN

Mouse Anti-NID2 Recombinant Antibody (4G8) (CBMAB-N2454-WJ)

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Target: NID2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4G8

Application*: E, WB

Rat Anti-NID2 Recombinant Antibody (CBWJN-1405) (CBMAB-N2453-WJ)

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Target: NID2

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBWJN-1405

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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