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  • Rabbit Anti-NKD1 Recombinant Antibody (CBWJN-1413)

Rabbit Anti-NKD1 Recombinant Antibody (CBWJN-1413) (CBMAB-N2528-WJ)

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Basic Information

Host Animal
Rabbit
Clone
CBWJN-1413
Application
WB, IP, IHC-P, ICC
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
pH 7.2, 49% PBS, 50% Glycerol, 0.05% BSA
Preservative
0.01% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Naked Cuticle Homolog 1
Introduction
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Entrez Gene ID
Human85407
Mouse93960
Rat364952
UniProt ID
HumanQ969G9
MouseQ99MH6
RatD4AAV5
Alternative Names
Naked Cuticle Homolog 1; Naked-1; Naked Cuticle Homolog 1 (Drosophila); Protein Naked Cuticle Homolog 1; Dvl-Binding Protein; Naked Cuticle-1;
Function
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
Biological Process
Eye photoreceptor cell differentiationBy SimilarityISS:BHF-UCL
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of convergent extension involved in axis elongationISS:BHF-UCL
Negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of non-canonical Wnt signaling pathway via JNK cascadeISS:BHF-UCL
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of Wnt signaling pathway, planar cell polarity pathwayISS:BHF-UCL
Regulation of cell migration involved in somitogenic axis elongationBy SimilarityISS:BHF-UCL
Somatic muscle developmentBy SimilarityISS:BHF-UCL
Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Cell membrane
Cytoplasm

Li, L., Gao, R., Huangfu, W., Zhang, F., Wang, R., & Liu, H. (2023). Clinical Significance of NKD Inhibitor of WNT Signaling Pathway 1 (NKD1) in Glioblastoma. Genetics Research, 2023, e16.

Bell, I., Khan, H., Stutt, N., Horn, M., Hydzik, T., Lum, W., ... & Van Raay, T. J. (2023). Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling. bioRxiv, 2023-10.

Wang, Y., Yang, C., Li, W., Shen, Y., Deng, J., Lu, W., ... & Liu, Q. (2021). Identification of colon tumor marker NKD1 via integrated bioinformatics analysis and experimental validation. Cancer medicine, 10(20), 7383-7394.

Gammons, M. V., Renko, M., Flack, J. E., Mieszczanek, J., & Bienz, M. (2020). Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin. Elife, 9, e59879.

Gammons, M., Renko, M., Flack, J. E., Mieszczanek, J., & Bienz, M. (2020). Feedback control of Wnt signaling based on histidine cluster co-aggregation between Naked/NKD and Axin. bioRxiv, 2020-06.

Guo, J. C., Yang, Y. J., Zheng, J. F., Zhang, J. Q., Guo, M., Yang, X., ... & Zhuo, L. (2019). Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells. Experimental & molecular medicine, 51(11), 1-20.

Li, W., Yang, C. J., Wang, L. Q., Wu, J., Dai, C., Yuan, Y. M., ... & Yao, M. C. (2019). A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells. Chinese Medicine, 14(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Rabbit Anti-NKD1 Recombinant Antibody (CBWJN-0604) (CAT#: CBMAB-N2529-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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