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NKD1

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

Full Name

Naked Cuticle Homolog 1

Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.

Biological Process

Eye photoreceptor cell differentiationBy SimilarityISS:BHF-UCL
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of convergent extension involved in axis elongationISS:BHF-UCL
Negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of non-canonical Wnt signaling pathway via JNK cascadeISS:BHF-UCL
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of Wnt signaling pathway, planar cell polarity pathwayISS:BHF-UCL
Regulation of cell migration involved in somitogenic axis elongationBy SimilarityISS:BHF-UCL
Somatic muscle developmentBy SimilarityISS:BHF-UCL
Wnt signaling pathwayIEA:UniProtKB-KW

Cellular Location

Cell membrane
Cytoplasm

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Anti-NKD1 antibodies

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Rabbit Anti-NKD1 Recombinant Antibody (C30F10) (CBMAB-N2527-WJ)

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Target: NKD1

Host: Rabbit

Specificity: Human

Clone: C30F10

Application*: WB, IP

Rabbit Anti-NKD1 Recombinant Antibody (CBWJN-0604) (CBMAB-N2529-WJ)

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Target: NKD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-0604

Application*: IP, WB

Rabbit Anti-NKD1 Recombinant Antibody (CBWJN-1413) (CBMAB-N2528-WJ)

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Target: NKD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJN-1413

Application*: WB, IP, P, IC

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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