NKD1
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Full Name
Naked Cuticle Homolog 1
Function
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
Biological Process
Eye photoreceptor cell differentiationBy SimilarityISS:BHF-UCL
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of convergent extension involved in axis elongationISS:BHF-UCL
Negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of non-canonical Wnt signaling pathway via JNK cascadeISS:BHF-UCL
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of Wnt signaling pathway, planar cell polarity pathwayISS:BHF-UCL
Regulation of cell migration involved in somitogenic axis elongationBy SimilarityISS:BHF-UCL
Somatic muscle developmentBy SimilarityISS:BHF-UCL
Wnt signaling pathwayIEA:UniProtKB-KW
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of convergent extension involved in axis elongationISS:BHF-UCL
Negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of non-canonical Wnt signaling pathway via JNK cascadeISS:BHF-UCL
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of Wnt signaling pathway, planar cell polarity pathwayISS:BHF-UCL
Regulation of cell migration involved in somitogenic axis elongationBy SimilarityISS:BHF-UCL
Somatic muscle developmentBy SimilarityISS:BHF-UCL
Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Cell membrane
Cytoplasm
Cytoplasm
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Anti-NKD1 antibodies
+ Filters

Target: NKD1
Host: Rabbit
Specificity: Human
Clone: C30F10
Application*: WB, IP
Target: NKD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0604
Application*: IP, WB
Target: NKD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1413
Application*: WB, IP, P, IC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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