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Mouse Anti-NKIRAS1 Recombinant Antibody (184C278) (CBMAB-K2184-LY)

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Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
184C278
Application
WB
Immunogen
Synthetic peptide corresponding to residues 96-113 of human kB-Ras1
Specificity
Human, Cattle, Dog, Horse, Mouse, Pig, Rat, Frog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% gelatin
Preservative
0.05% sodium azide
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
NFKB inhibitor interacting Ras-like 1
Introduction
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Entrez Gene ID
Human28512
Mouse69721
Rat305751
Cattle522875
Dog477047
Horse100051752
Pig100620195
Frog100489722
UniProt ID
HumanQ9NYS0
MouseQ8CEC5
RatB5DFJ1
CattleQ0VC61
DogE2QXE8
HorseF6SGK6
PigI3L911
FrogA0JMW9
Alternative Names
NFKB Inhibitor Interacting Ras Like 1; NFKB Inhibitor Interacting Ras-Like Protein 1; I-Kappa-B-Interacting Ras-Like Protein 1; Kappa B-Ras Protein 1; KappaB-Ras1; KBRAS1; NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 1; Kappa B-Ras 1;
Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Biological Process
I-kappaB kinase/NF-kappaB signaling1 PublicationNAS:UniProtKB
Lung alveolus developmentIEA:Ensembl
Ral protein signal transductionIEA:Ensembl
Regulation of tumor necrosis factor-mediated signaling pathwayIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Cellular Location
Cytoplasm

Postler, T. S., Wang, A., Brundu, F. G., Wang, P., Wu, Z., Butler, K. E., ... & Ghosh, S. (2023). A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Proceedings of the National Academy of Sciences, 120(46), e2312595120.

Sarais, F., Rebl, H., Verleih, M., Ostermann, S., Krasnov, A., Köllner, B., ... & Rebl, A. (2020). Characterisation of the teleostean κB-Ras family: The two members NKIRAS1 and NKIRAS2 from rainbow trout influence the activity of NF-κB in opposite ways. Fish & Shellfish Immunology, 106, 1004-1013.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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