Sign in or Register
  • Home
  • NKIRAS2
  • Mouse Anti-NKIRAS2 Recombinant Antibody (2G9)

Mouse Anti-NKIRAS2 Recombinant Antibody (2G9) (CBMAB-N2540-WJ)

See all NKIRAS2 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
2G9
Application
ELISA, IHC-P, WB
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
NFKB inhibitor interacting Ras-like 2
Introduction
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Entrez Gene ID
28511
UniProt ID
Q9NYR9
Alternative Names
NFKB Inhibitor Interacting Ras Like 2; NFKB Inhibitor Interacting Ras-Like Protein 2; I-Kappa-B-Interacting Ras-Like Protein 2; Kappa B-Ras Protein 2; KappaB-Ras2; KBRAS2; NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 2; NFKB Inhibitor Interacting Ras-Like 2;
Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Biological Process
I-kappaB kinase/NF-kappaB signaling1 PublicationNAS:UniProtKB
Inflammatory responseIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Ral protein signal transductionIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Regulation of tumor necrosis factor-mediated signaling pathwayIEA:Ensembl
Surfactant homeostasisIEA:Ensembl
Cellular Location
Cytoplasm

Zhou, X., Qiu, G., Yang, Y., Bao, W., Zhang, D., & Du, X. (2023). Circ_0001955 promotes non‐small cell lung cancer cell proliferation and invasion by regulating MiR‐29a‐3p/NKIRAS2 axis to activate the nuclear factor‐κB pathway. Pathology International, 73(9), 434-443.

Luoreng, Z. M., Wei, D. W., & Wang, X. P. (2021). MiR-125b regulates inflammation in bovine mammary epithelial cells by targeting the NKIRAS2 gene. Veterinary research, 52, 1-10.

Zheng, H. L., Yang, R. Z., Xu, W. N., Liu, T., Chen, P. B., Zheng, X. F., ... & Jiang, S. D. (2020). Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma. Aging (Albany NY), 12(18), 18571.

Sarais, F., Rebl, H., Verleih, M., Ostermann, S., Krasnov, A., Köllner, B., ... & Rebl, A. (2020). Characterisation of the teleostean κB-Ras family: The two members NKIRAS1 and NKIRAS2 from rainbow trout influence the activity of NF-κB in opposite ways. Fish & Shellfish Immunology, 106, 1004-1013.

Ding, Y., Bi, L., & Wang, J. (2020). MiR-1180 promotes cardiomyocyte cell cycle re-entry after injury through the NKIRAS2–NFκB pathway. Biochemistry and Cell Biology, 98(4), 449-457.

Xu, Y. J., Zhou, R., Zong, J. F., Lin, W. S., Tong, S., Guo, Q. J., ... & Pan, J. J. (2019). Epstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway. Cancer letters, 447, 33-40.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NKIRAS2 Recombinant Antibody (2G9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry