Mouse Anti-NKIRAS2 Recombinant Antibody (2G9) (CBMAB-N2540-WJ)

This product is a Mouse antibody that recognizes NKIRAS2. The antibody 2G9 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all NKIRAS2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2G9

Antibody Isotype

IgG1, κ

Application

ELISA, IHC-P, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

NFKB inhibitor interacting Ras-like 2

Introduction

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Entrez Gene ID

28511

UniProt ID

Q9NYR9

Alternative Names

NFKB Inhibitor Interacting Ras Like 2; NFKB Inhibitor Interacting Ras-Like Protein 2; I-Kappa-B-Interacting Ras-Like Protein 2; Kappa B-Ras Protein 2; KappaB-Ras2; KBRAS2; NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 2; NFKB Inhibitor Interacting Ras-Like 2;

Function

Biological Process

I-kappaB kinase/NF-kappaB signaling1 PublicationNAS:UniProtKB
Inflammatory responseIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Ral protein signal transductionIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Regulation of tumor necrosis factor-mediated signaling pathwayIEA:Ensembl
Surfactant homeostasisIEA:Ensembl

Cellular Location

Cytoplasm

References

Zhou, X., Qiu, G., Yang, Y., Bao, W., Zhang, D., & Du, X. (2023). Circ_0001955 promotes non‐small cell lung cancer cell proliferation and invasion by regulating MiR‐29a‐3p/NKIRAS2 axis to activate the nuclear factor‐κB pathway. Pathology International, 73(9), 434-443.

Luoreng, Z. M., Wei, D. W., & Wang, X. P. (2021). MiR-125b regulates inflammation in bovine mammary epithelial cells by targeting the NKIRAS2 gene. Veterinary research, 52, 1-10.

Zheng, H. L., Yang, R. Z., Xu, W. N., Liu, T., Chen, P. B., Zheng, X. F., ... & Jiang, S. D. (2020). Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma. Aging (Albany NY), 12(18), 18571.

Sarais, F., Rebl, H., Verleih, M., Ostermann, S., Krasnov, A., Köllner, B., ... & Rebl, A. (2020). Characterisation of the teleostean κB-Ras family: The two members NKIRAS1 and NKIRAS2 from rainbow trout influence the activity of NF-κB in opposite ways. Fish & Shellfish Immunology, 106, 1004-1013.

Ding, Y., Bi, L., & Wang, J. (2020). MiR-1180 promotes cardiomyocyte cell cycle re-entry after injury through the NKIRAS2–NFκB pathway. Biochemistry and Cell Biology, 98(4), 449-457.

Xu, Y. J., Zhou, R., Zong, J. F., Lin, W. S., Tong, S., Guo, Q. J., ... & Pan, J. J. (2019). Epstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway. Cancer letters, 447, 33-40.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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