NKIRAS2

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

NFKB inhibitor interacting Ras-like 2

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

I-kappaB kinase/NF-kappaB signaling1 PublicationNAS:UniProtKB
Inflammatory responseIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Ral protein signal transductionIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Regulation of tumor necrosis factor-mediated signaling pathwayIEA:Ensembl
Surfactant homeostasisIEA:Ensembl

Cytoplasm