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Mouse Anti-NKRF Recombinant Antibody (CBWJN-0318) (CBMAB-N0391-WJ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBWJN-0318
Application
Dot, WB
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
NFKB repressing factor
Introduction
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Entrez Gene ID
55922
UniProt ID
O15226
Alternative Names
NFKB Repressing Factor; Transcription Factor NRF; ITBA4; NRF; NF-Kappa-B-Repressing Factor; NF-KappaB Repressing Factor; NFkB-Repressing Factor; Protein ITBA4;
Function
Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793).
Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793).
Also involved in the regulation of IL-8 transcription (PubMed:12381793).
May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553).
Biological Process
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Cellular Location
Nucleus, nucleolus

Wang, W. F., Zhong, H. J., Cheng, S., Fu, D., Zhao, Y., Cai, H. M., ... & Zhao, W. L. (2023). A nuclear NKRF interacting long noncoding RNA controls EBV eradication and suppresses tumor progression in natural killer/T-cell lymphoma. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1869(6), 166722.

Lu, J., Shi, Y., Zhang, F., Zhang, Y., Zhao, X., Zheng, H., ... & Zhao, L. (2023). Mechanism of lnRNA-ICL involved in lung cancer development in COPD patients through modulating microRNA-19-3p/NKRF/NF-κB axis. Cancer Cell International, 23(1), 58.

Zhang, Y., Meng, T., Chen, J., Zhang, Y., Kang, J., Li, X., ... & Ning, B. (2021). miR-21a-5p promotes inflammation following traumatic spinal cord injury through upregulation of neurotoxic reactive astrocyte (A1) polarization by inhibiting the CNTF/STAT3/Nkrf pathway. International Journal of Biological Sciences, 17(11), 2795.

Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X., ... & He, X. (2020). Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling. International Journal of Oncology, 57(2), 522-532.

Chen, X. J., Zhang, W. N., Chen, B., Xi, W. D., Lu, Y., Huang, J. Y., ... & Chen, S. J. (2019). Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor. Proceedings of the National Academy of Sciences, 116(6), 2220-2225.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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