NKRF

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. [provided by RefSeq]
Full Name
NFKB repressing factor
Function
Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793).
Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793).
Also involved in the regulation of IL-8 transcription (PubMed:12381793).
May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553).
Biological Process
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Cellular Location
Nucleus, nucleolus
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Anti-NKRF antibodies

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Mouse Anti-NKRF Recombinant Antibody (CBWJN-0493) (CBMAB-N2543-WJ)

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Target: NKRF
Host: Mouse
Specificity: Human
Clone: CBWJN-0493
Application*: DB, WB
Datasheet SDS

Mouse Anti-NKRF Recombinant Antibody (4C2) (CBMAB-N2542-WJ)

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Target: NKRF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4C2
Application*: WB
Datasheet SDS

Mouse Anti-NKRF Recombinant Antibody (1F6) (CBMAB-N2541-WJ)

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Target: NKRF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F6
Application*: E, WB
Datasheet SDS

Mouse Anti-NKRF Recombinant Antibody (CBWJN-0318) (CBMAB-N0391-WJ)

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Target: NKRF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0318
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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