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NKRF

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. [provided by RefSeq]

Full Name

NFKB repressing factor

Function

Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793).
Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793).
Also involved in the regulation of IL-8 transcription (PubMed:12381793).
May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553).

Biological Process

Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB

Cellular Location

Nucleus, nucleolus

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Anti-NKRF antibodies

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Mouse Anti-NKRF Recombinant Antibody (CBWJN-0493) (CBMAB-N2543-WJ)

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Target: NKRF

Host: Mouse

Specificity: Human

Clone: CBWJN-0493

Application*: DB, WB

Mouse Anti-NKRF Recombinant Antibody (4C2) (CBMAB-N2542-WJ)

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Target: NKRF

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4C2

Application*: WB

Mouse Anti-NKRF Recombinant Antibody (1F6) (CBMAB-N2541-WJ)

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Target: NKRF

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F6

Application*: E, WB

Mouse Anti-NKRF Recombinant Antibody (CBWJN-0318) (CBMAB-N0391-WJ)

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Target: NKRF

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-0318

Application*: DB, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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