Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0800) (CBMAB-N0402-WJ)

Name: Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0800)
SKU: CBMAB-N0402-WJ
Rating: 5 (1 reviews)

See all NKX2-2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0800

Application

FC, IF, IHC-P, CyTOF

Specificity

Human, Mouse, Rat, Chicken

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NK2 Homeobox 2

Introduction

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	4821
Mouse	18088
Rat	366214
Chicken	428549

UniProt ID

Human	O95096
Mouse	P42586
Rat	D3ZDQ2
Chicken	A0A1D5PPK4

Alternative Names

NK2 Homeobox 2; Homeobox Protein NK-2 Homolog B; NKX2.2; NKX2B; NK2 Transcription Factor Related, Locus 2 (Drosophila); NK2 Transcription Factor Related, Locus 2; NK2 Transcription Factor-Like Protein B; NK-2 (Drosophila) Homolog B; Homeobox Protein Nkx-2.2;

Function

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).
May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).

Biological Process

Astrocyte differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Digestive tract developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate specificationIEA:Ensembl
Oligodendrocyte developmentIEA:Ensembl
Optic nerve developmentIEA:Ensembl
Pancreatic A cell fate commitmentIEA:Ensembl
Pancreatic PP cell fate commitmentIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseIEA:Ensembl
Response to progesteroneIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell fate commitmentIEA:Ensembl
Ventral spinal cord interneuron fate determinationIEA:Ensembl

Cellular Location

Nucleus

Kavitha, B., Srikanth, K., Singh, D., Gopi, S., Mohan, V., Chandra, N., & Radha, V. (2023). A novel stop-loss mutation in NKX2-2 gene as a cause of neonatal diabetes mellitus: molecular characterization and structural analysis. Acta Diabetologica, 1-6.

Seymour, P. A., & Serup, P. (2023). Differential use of the Nkx2. 2 NK2 domain in developing pancreatic islets and neurons. Genes & Development, 37(11-12), 451-453.

Abarinov, V., Levine, J. A., Churchill, A. J., Hopwood, B., Deiter, C. S., Guney, M. A., ... & Sussel, L. (2023). Major β cell-specific functions of NKX2. 2 are mediated via the NK2-specific domain. Genes & Development, 37(11-12), 490-504.

Berzanskyte, I., Riccio, F., Machado, C. B., Bradbury, E. J., & Lieberam, I. (2023). Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter. Scientific Reports, 13(1), 2008.

Zhang, C., Chen, Z., Zhang, D., Wang, X., Qiu, M., & Tan, Z. (2023). Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2. 2. Molecular Neurobiology, 1-12.

Machado, I., Charville, G. W., Yoshida, A., Navarro, S., Righi, A., Gambarotti, M., ... & Llombart-Bosch, A. (2022). Does PAX7 and NKX2. 2 immunoreactivity in Ewing sarcoma have prognostic significance?. Virchows Archiv, 480(4), 909-917.

Zhang, C., Huang, H., Chen, Z., Zhang, Z., Lu, W., & Qiu, M. (2020). The transcription factor NKX2-2 regulates oligodendrocyte differentiation through domain-specific interactions with transcriptional corepressors. Journal of Biological Chemistry, 295(7), 1879-1888.

Auerbach, A., Cohen, A., Ofek Shlomai, N., Weinberg-Shukron, A., Gulsuner, S., King, M. C., ... & Zangen, D. (2020). NKX2-2 mutation causes congenital diabetes and infantile obesity with paradoxical glucose-induced ghrelin secretion. The Journal of Clinical Endocrinology & Metabolism, 105(11), 3486-3495.

Mariyath, M. P., Shahi, M. H., Farheen, S., Tayyab, M., Khanam, N., & Ali, A. (2020). Novel homeodomain transcription factor Nkx2. 2 in the brain tumor development. Current Cancer Drug Targets, 20(5), 335-340.

Rooper, L. M., Sharma, R., Gocke, C. D., & Belchis, D. A. (2019). The utility of NKX2. 2 and TLE1 immunohistochemistry in the differentiation of Ewing sarcoma and synovial sarcoma. Applied Immunohistochemistry & Molecular Morphology, 27(3), 174-179.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0800)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-1414) (CAT#: CBMAB-N2566-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0762) (CAT#: CBMAB-N0400-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0352) (CAT#: CBMAB-N2568-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (A1371) (CAT#: CBMAB-AP5089LY)

Mouse Anti-NKX2-2 Recombinant Antibody (F-2) (CAT#: CBMAB-N2571-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (A1370) (CAT#: CBMAB-AP5090LY)

Mouse Anti-NKX2-2 Recombinant Antibody (3E4) (CAT#: CBMAB-N2565-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (PR-3B2) (CAT#: CBMAB-N2575-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (D-4) (CAT#: CBMAB-N2569-WJ)

Mouse Anti-NKX2-2 Recombinant Antibody (74.5A5) (CAT#: CBMAB-0284-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry