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NKX2-2

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
Full Name
NK2 Homeobox 2
Function
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).
May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Biological Process
Astrocyte differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Digestive tract developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate specificationIEA:Ensembl
Oligodendrocyte developmentIEA:Ensembl
Optic nerve developmentIEA:Ensembl
Pancreatic A cell fate commitmentIEA:Ensembl
Pancreatic PP cell fate commitmentIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseIEA:Ensembl
Response to progesteroneIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell fate commitmentIEA:Ensembl
Ventral spinal cord interneuron fate determinationIEA:Ensembl
Cellular Location
Nucleus
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Anti-NKX2-2 antibodies

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Mouse Anti-NKX2-2 Recombinant Antibody (74.5A5) (CBMAB-0284-CN)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Chicken, Human, Mouse, Rat
Clone: 74.5A5
Application*: P, IF, IH, WB
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBT2797) (V2LY-0625-LY2761)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2797
Application*: F
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (A1371) (CBMAB-AP5089LY)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Chicken, Human, Mouse
Clone: A1371
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (A1370) (CBMAB-AP5090LY)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Chicken, Human, Mouse
Clone: A1370
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (PR-3B2) (CBMAB-N2575-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: PR-3B2
Application*: WB
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (F-2) (CBMAB-N2571-WJ)

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Target: NKX2-2
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: F-2
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (D-4) (CBMAB-N2569-WJ)

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Target: NKX2-2
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: D-4
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0352) (CBMAB-N2568-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0352
Application*: E, F, WB
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0142) (CBMAB-N2567-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0142
Application*: E
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-1414) (CBMAB-N2566-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJN-1414
Application*: WB, IC
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (3E4) (CBMAB-N2565-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E4
Application*: F, E, WB
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0800) (CBMAB-N0402-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Chicken
Clone: CBWJN-0800
Application*: F, IF, P, MC
Datasheet SDS

Rabbit Anti-NKX2-2 Recombinant Antibody (CBWJN-0795) (CBMAB-N0401-WJ)

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Target: NKX2-2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0795
Application*: IF, P
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0762) (CBMAB-N0400-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Chicken
Clone: CBWJN-0762
Application*: F, IF, P, C
Datasheet SDS

Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0759) (CBMAB-N0398-WJ)

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Target: NKX2-2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0759
Application*: F, IF, P, MC
Datasheet SDS

Rabbit Anti-NKX2-2 Recombinant Antibody (CBWJN-0757) (CBMAB-N0397-WJ)

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Target: NKX2-2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0757
Application*: F, P, IF, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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