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Mouse Anti-NKX2-3 Recombinant Antibody (4F4) (CBMAB-N2576-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NK2 transcription factor related, locus 3 (Drosophila)
Introduction
This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]
Entrez Gene ID
159296
UniProt ID
Q8TAU0
Alternative Names
NK2 Homeobox 3; Homeobox Protein NK-2 Homolog C; NKX2C; NK2 Transcription Factor Related, Locus 3 (Drosophila); NK2 Transcription Factor Related, Locus 3; NK-2 (Drosophila) Homolog C; Homeobox Protein Nkx-2.3;
Function
Transcription factor.
Biological Process
CD4-positive, alpha-beta T cell differentiationIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Gland morphogenesisIEA:Ensembl
Leukocyte homeostasisIEA:Ensembl
Leukocyte migrationIEA:Ensembl
Lymph node developmentIEA:Ensembl
Macrophage differentiationIEA:Ensembl
Odontogenesis of dentin-containing toothIEA:Ensembl
Peyer's patch developmentIEA:Ensembl
Plasma cell differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Post-embryonic digestive tract morphogenesisIEA:Ensembl
Regulation of cell population proliferationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spleen developmentIEA:Ensembl
Triglyceride metabolic processIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Gábris, F., Kajtár, B., Kellermayer, Z., & Balogh, P. (2024). Quantitative Analysis of NKX2-3 Expression in Human Colon: An Immunohistochemical Study. Journal of Histochemistry & Cytochemistry, 72(1), 11-23.

Gao, X., Mukaibo, T., Wei, X., Faustoferri, R. C., Oei, M. S., Hwang, S. K., ... & Ovitt, C. E. (2024). Nkx2. 3 transcription factor is a key regulator of mucous cell identity in salivary glands. Developmental Biology.

Hu, M., Chen, N., Chen, M., Chen, F., Lu, Y., Xu, Y., ... & Wang, J. (2023). Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy. Leukemia, 1-14.

Gábris, F., Kiss, G., Szirmay, B., Szomor, Á., Berta, G., Jakus, Z., ... & Balogh, P. (2023). Absence of Nkx2-3 induces ectopic lymphatic endothelial differentiation associated with impaired extramedullary stress hematopoiesis in the spleen. Frontiers in Cell and Developmental Biology, 11, 1170389.

Yang, S., Xu, X., Yin, Z., Liu, Y., Wang, H., Guo, J., ... & Sun, S. (2023). nkx2. 3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. Heliyon, 9(11).

Zheng, H., Zhai, W., Zhong, C., Hong, Q., Li, H., Rui, B., ... & Yang, P. (2021). Nkx2‐3 induces autophagy inhibiting proliferation and migration of vascular smooth muscle cells via AMPK/mTOR signaling pathway. Journal of Cellular Physiology, 236(11), 7342-7355.

Nagel, S., Pommerenke, C., Meyer, C., & MacLeod, R. A. (2021). NKL homeobox genes NKX2-3 and NKX2-4 deregulate megakaryocytic-erythroid cell differentiation in AML. International Journal of Molecular Sciences, 22(21), 11434.

Khanfar, E., Olasz, K., Gábris, F., Gajdócsi, E., Botz, B., Kiss, T., ... & Boldizsár, F. (2020). Ameliorated Autoimmune Arthritis and Impaired B Cell Receptor-Mediated Ca2+ Influx in Nkx2-3 Knock-out Mice. International Journal of Molecular Sciences, 21(17), 6162.

Kerkhofs, C., Stevens, S. J., Faust, S. N., Rae, W., Williams, A. P., Wurm, P., ... & Brunner, H. G. (2020). Mutations in RPSA and NKX2‐3 link development of the spleen and intestinal vasculature. Human Mutation, 41(1), 196-202.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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