Mouse Anti-NLE1 Recombinant Antibody (G-5) (CBMAB-N2635-WJ)

Name: Mouse Anti-NLE1 Recombinant Antibody (G-5)
SKU: CBMAB-N2635-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

G-5

Application

WB, IP, IF, ELISA

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Notchless Homolog 1

Introduction

Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Entrez Gene ID

54475

UniProt ID

Q9NVX2

Alternative Names

Notchless Homolog 1; Notchless Gene Homolog, (Drosophila); Notchless Homolog (Drosophila); Notchless Protein Homolog 1; Notchless Gene Homolog; NLE;

Function

Biological Process

Hematopoietic stem cell homeostasisIEA:Ensembl
Inner cell mass cell differentiationIEA:Ensembl
Kidney developmentIEA:Ensembl
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEA:Ensembl
Negative regulation of mitotic cell cycleIEA:Ensembl
Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Ribosomal large subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Skeletal system morphogenesisIEA:Ensembl
SomitogenesisIEA:Ensembl

Cellular Location

Nucleus, nucleolus

Xu, P., Wang, L., Mo, B., Xie, X., Hu, R., Jiang, L., ... & Xiao, H. (2023). Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer. Frontiers in Oncology, 12, 985827.

Wang, Y., & Xu, Z. (2023). The effect of up-regulation of NLE1 gene expression on the invasion and migration of colon cancer cells and its mechanism. Journal of King Saud University-Science, 35(5), 102669.

Ren, Z., Ni, F., Zhang, T., Yuan, X., & Li, J. (2021). Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma. Experimental Cell Research, 404(2), 112636.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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