Mouse Anti-NLGN4Y Recombinant Antibody (2F7) (CBMAB-N2656-WJ)

Name: Mouse Anti-NLGN4Y Recombinant Antibody (2F7)
SKU: CBMAB-N2656-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F7

Application

ELISA, IP, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuroligin 4, Y-Linked

Introduction

This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Mar 2011]

Entrez Gene ID

22829

UniProt ID

Q8NFZ3

Alternative Names

Neuroligin 4, Y-Linked; Neuroligin 4, Y Linked; Neuroligin Y; KIAA0951;

Function

Putative neuronal cell surface protein involved in cell-cell-interactions.

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
LearningManual Assertion Based On ExperimentIMP:BHF-UCL
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Neuron cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Postsynaptic membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Presynapse assemblyManual Assertion Based On ExperimentTAS:ARUK-UCL
Presynaptic membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane
Cell junction, synapse, postsynaptic density membrane

Topology

Extracellular: 44-676
Helical: 677-697
Cytoplasmic: 698-816

Nardello, R., Antona, V., Mangano, G. D., Salpietro, V., Mangano, S., & Fontana, A. (2021). A paradigmatic autistic phenotype associated with loss of PCDH11Y and NLGN4Y genes. BMC Medical Genomics, 14(1), 1-5.

Nguyen, T. A., Wu, K., Pandey, S., Lehr, A. W., Li, Y., Bemben, M. A., ... & Roche, K. W. (2020). A cluster of autism-associated variants on X-linked NLGN4X functionally resemble NLGN4Y. Neuron, 106(5), 759-768.

Maxeiner, S., Sester, M., & Krasteva-Christ, G. (2019). Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y. Biology of sex Differences, 10(1), 1-8.

Ross, J. L., Bloy, L., Roberts, T. P., Miller, J., Xing, C., Silverman, L. A., & Zinn, A. R. (2019). Y chromosome gene copy number and lack of autism phenotype in a male with an isodicentric Y chromosome and absent NLGN4Y expression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(7), 471-482.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

NLGN4Y Matched Antibody Pair (802) (CAT#: APMAB-802LY)

Related Products

Mouse Anti-NLGN4Y Recombinant Antibody (1E4) (CAT#: CBMAB-N2655-WJ)

NLGN4Y Matched Antibody Pair (802) (CAT#: APMAB-802LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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