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Mouse Anti-NLN Recombinant Antibody (CBYJL-269) (CBMAB-L0386-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Neurolysin (NLN). The antibody can be used for immunoassay techniques, such as IHC-P.
See all NLN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-269
Antibody Isotype
IgG2b
Application
IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human NLN(NP_065777) produced in HEK293T cell.ImmunogenType: Recombinant protein.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurolysin
Introduction
NLN is a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, resulting in the formation of neurotensin(1-10) and neurotensin(11-13). NLN is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.
Entrez Gene ID
57486
UniProt ID
Q9BYT8
Alternative Names
Neurolysin; Neurotensin Endopeptidase; Neurolysin (Metallopeptidase M3 Family); Mitochondrial Oligopeptidase M; Angiotensin Binding Protein; Microsomal Endopeptidase; EC 3.4.24.16; AGTBP; MEP
Function
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.
Biological Process
G protein-coupled receptor signaling pathwayTAS:Reactome
Peptide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gluconeogenesisIEA:Ensembl
Regulation of skeletal muscle fiber differentiationIEA:Ensembl
Cellular Location
Mitochondrion intermembrane space
Cytoplasm

Caprioli, B., Eichler, R. A., Silva, R. N., Martucci, L. F., Reckziegel, P., & Ferro, E. S. (2023). Neurolysin Knockout Mice in a Diet-Induced Obesity Model. International Journal of Molecular Sciences, 24(20), 15190.

Esfahani, S. H., Abbruscato, T. J., Trippier, P. C., & Karamyan, V. T. (2022). Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy. Expert Opinion on Therapeutic Targets, 26(5), 401-404.

Karamyan, V. T. (2021). The role of peptidase neurolysin in neuroprotection and neural repair after stroke. Neural Regeneration Research, 16(1), 21.

Jayaraman, S., Kocot, J., Esfahani, S. H., Wangler, N. J., Uyar, A., Mechref, Y., ... & Karamyan, V. T. (2021). Identification and characterization of two structurally related dipeptides that enhance catalytic efficiency of neurolysin. Journal of Pharmacology and Experimental Therapeutics, 379(2), 191-202.

Jayaraman, S., Al Shoyaib, A., Kocot, J., Villalba, H., Alamri, F. F., Rashid, M., ... & Karamyan, V. T. (2020). Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice. Journal of neurochemistry, 153(1), 120-137.

Mirali, S., Botham, A., Voisin, V., Xu, C., St-Germain, J., Sharon, D., ... & Schimmer, A. D. (2020). The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability. Science Translational Medicine, 12(538), eaaz8264.

Karamyan, V. T. (2019). Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders. Medical hypotheses, 131, 109309.

Mirali, S., Aaron, B., Voisin, V., Xu, C., St-Germain, J., Sharon, D., ... & Schimmer, A. D. (2019). The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability. Blood, 134, 729.

Jayaraman, S., Rashid, M., Wangler, N. J., Villalba, H., German, N., Arumugam, T. V., ... & Karamyan, V. T. (2019). Peptidase Neurolysin Functions to Preserve the Brain After Ischemic Stroke in Mice. Stroke, 50(Suppl_1), A157-A157.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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