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Mouse Anti-NLRC5 Recombinant Antibody (B-10) (CBMAB-N2676-WJ)

This product is a Mouse antibody that recognizes NLRC5. The antibody B-10 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NLRC5 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
B-10
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR family, CARD domain containing 5
Introduction
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Mouse434341
Rat291861
UniProt ID
MouseC3VPR6
RatM0R4M1
Alternative Names
NLR Family CARD Domain Containing 5; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 5; Nucleotide-Binding Oligomerization Domain Protein 4; Caterpiller Protein 16.1; NOD-Like Receptor C5; CLR16.1;
Function
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
Biological Process
Defense response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of type I interferon-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interferon-gamma-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MHC class I biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of type I interferon-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm

Zhan, L., Zhang, J., Zhang, J., Liu, X., Zhu, S., Shi, Y., ... & Cao, Y. (2022). LC3 and NLRC5 interaction inhibits NLRC5-mediated MHC class I antigen presentation pathway in endometrial cancer. Cancer letters, 529, 37-52.

Yoshihama, S., Cho, S. X., Yeung, J., Pan, X., Lizee, G., Konganti, K., ... & Kobayashi, K. S. (2021). NLRC5/CITA expression correlates with efficient response to checkpoint blockade immunotherapy. Scientific reports, 11(1), 3258.

Cho, S. X., Vijayan, S., Yoo, J. S., Watanabe, T., Ouda, R., An, N., & Kobayashi, K. S. (2021). MHC class I transactivator NLRC5 in host immunity, cancer and beyond. Immunology, 162(3), 252-261.

Shukla, A., Cloutier, M., Appiya Santharam, M., Ramanathan, S., & Ilangumaran, S. (2021). The MHC class-I transactivator NLRC5: implications to cancer immunology and potential applications to cancer immunotherapy. International Journal of Molecular Sciences, 22(4), 1964.

Tang, F., Xu, Y., & Zhao, B. (2020). NLRC5: new cancer buster?. Molecular Biology Reports, 47(3), 2265-2277.

Liu, Y. R., Yang, L., Xu, Q. Q., Lu, X. Y., Ma, T. T., Huang, C., & Li, J. (2019). Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. Journal of cellular physiology, 234(8), 14270-14284.

Luan, P., Jian, W., Xu, X., Kou, W., Yu, Q., Hu, H., ... & Peng, W. (2019). NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ. Nature communications, 10(1), 2882.

Wu, Y., Shi, T., & Li, J. (2019). NLRC5: A paradigm for NLRs in immunological and inflammatory reaction. Cancer letters, 451, 92-99.

Wang, J. Q., Liu, Y. R., Xia, Q., Chen, R. N., Liang, J., Xia, Q. R., & Li, J. (2019). Emerging roles for NLRC5 in immune diseases. Frontiers in Pharmacology, 10, 1352.

Wang, M., Wang, L., Fang, L., Li, S., & Liu, R. (2019). NLRC5 negatively regulates LTA‐induced inflammation via TLR2/NF‐κB and participates in TLR2‐mediated allergic airway inflammation. Journal of Cellular Physiology, 234(11), 19990-20001.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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