NLRC5

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways.

Full Name

NLR family, CARD domain containing 5

Function

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.

Biological Process

Defense response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of type I interferon-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interferon-gamma-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MHC class I biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of type I interferon-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of kinase activityManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm