Mouse Anti-NLRP10 Recombinant Antibody (CBWJN-1433) (CBMAB-N2681-WJ)

Name: Mouse Anti-NLRP10 Recombinant Antibody (CBWJN-1433)
SKU: CBMAB-N2681-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-1433

Application

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 5% Trehalose

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NLR Family Pyrin Domain Containing 10

Introduction

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	338322
Mouse	244202
Rat	293426

UniProt ID

Human	Q86W26
Mouse	Q8CCN1
Rat	D3ZUA2

Alternative Names

NLR Family Pyrin Domain Containing 10; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 10; Nucleotide-Binding Oligomerization Domain Protein 8; NACHT, Leucine Rich Repeat And PYD Containing 10; NALP10; PYNOD;

Function

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476).
Displays anti-inflammatory activity (PubMed:20393137).
Required for immunity against C.albicans infection (By similarity).
Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233).
Contributes to T-cell-mediated inflammatory responses in the skin (By similarity).
Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990).
Exhibits both ATPase and GTPase activities (PubMed:23861819).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Defense response to fungusISS:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of inflammatory responseISS:UniProtKB
Positive regulation of interleukin-1 alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of T-helper 1 type immune responseISS:UniProtKB
Positive regulation of T-helper 17 type immune responseISS:UniProtKB

Nguyen, K. T. (2023). NLRP10 is cleaved by diverse flavivirus proteases and is a potent regulator of inflammasome activation (Doctoral dissertation, UC San Diego).

Próchnicki, T., Vasconcelos, M. B., Robinson, K. S., Mangan, M. S., De Graaf, D., Shkarina, K., ... & Latz, E. (2023). Mitochondrial damage activates the NLRP10 inflammasome. Nature Immunology, 24(4), 595-603.

Masters, S. L. (2023). Ten things to know about NLRP10. Nature Immunology, 24(4), 561-562.

Zheng, D., Mohapatra, G., Kern, L., He, Y., Shmueli, M. D., Valdés-Mas, R., ... & Elinav, E. (2023). Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation. Nature immunology, 24(4), 585-594.

Yi, X., Song, Y., Xu, J., Wang, L., Liu, L., Huang, D., & Zhang, L. (2023). NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells. Odontology, 1-12.

Latz, E., Próchnicki, T., Vasconcelos, M. B., Mangan, M., Robinson, K., Rösing, S., ... & Zhong, F. (2022). Mitochondrial damage activates the NLRP10 inflammasome.

Li, Z. G., Shui, S. F., Han, X. W., & Yan, L. (2020). NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation. Experimental Cell Research, 389(2), 111912.

Mirza, N., Sowa, A. S., Lautz, K., & Kufer, T. A. (2019). NLRP10 affects the stability of abin-1 to control inflammatory responses. The Journal of Immunology, 202(1), 218-227.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
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For research use only. Not intended for any clinical use.

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