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Mouse Anti-NLRP10 Recombinant Antibody (CBWJN-1433) (CBMAB-N2681-WJ)

This product is a Mouse antibody that recognizes NLRP10. The antibody CBWJN-1433 can be used for immunoassay techniques such as: WB.
See all NLRP10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-1433
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 5% Trehalose
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR Family Pyrin Domain Containing 10
Introduction
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human338322
Mouse244202
Rat293426
UniProt ID
HumanQ86W26
MouseQ8CCN1
RatD3ZUA2
Alternative Names
NLR Family Pyrin Domain Containing 10; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 10; Nucleotide-Binding Oligomerization Domain Protein 8; NACHT, Leucine Rich Repeat And PYD Containing 10; NALP10; PYNOD;
Function
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476).
Displays anti-inflammatory activity (PubMed:20393137).
Required for immunity against C.albicans infection (By similarity).
Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233).
Contributes to T-cell-mediated inflammatory responses in the skin (By similarity).
Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990).
Exhibits both ATPase and GTPase activities (PubMed:23861819).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Defense response to fungusISS:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of inflammatory responseISS:UniProtKB
Positive regulation of interleukin-1 alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of T-helper 1 type immune responseISS:UniProtKB
Positive regulation of T-helper 17 type immune responseISS:UniProtKB
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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