NLRP10

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.

Full Name

NLR Family Pyrin Domain Containing 10

Function

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476).
Displays anti-inflammatory activity (PubMed:20393137).
Required for immunity against C.albicans infection (By similarity).
Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233).
Contributes to T-cell-mediated inflammatory responses in the skin (By similarity).
Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990).
Exhibits both ATPase and GTPase activities (PubMed:23861819).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Defense response to fungusISS:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of inflammatory responseISS:UniProtKB
Positive regulation of interleukin-1 alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of T-helper 1 type immune responseISS:UniProtKB
Positive regulation of T-helper 17 type immune responseISS:UniProtKB