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Mouse Anti-NLRP7 Recombinant Antibody (CBWJN-0161) (CBMAB-N2709-WJ)

This product is a Mouse antibody that recognizes NLRP7. The antibody CBWJN-0161 can be used for immunoassay techniques such as: WB, IP.
See all NLRP7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBWJN-0161
Antibody Isotype
IgG1, κ
Application
WB, IP

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR Family Pyrin Domain Containing 7
Introduction
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
199713
UniProt ID
Q8WX94
Alternative Names
NLR Family Pyrin Domain Containing 7; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 7; Nucleotide-Binding Oligomerization Domain Protein 12; NACHT, Leucine Rich Repeat And PYD Containing 7; PYPAF3; NALP7; NOD12; NACHT, LRR And PYD Domains-Containing Protein 7;
Function
Inhibits CASP1/caspase-1-dependent IL1B secretion.
Biological Process
Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of aspartic-type peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein processingManual Assertion Based On ExperimentIDA:UniProtKB

Abi Nahed, R., Elkhoury Mikhael, M., Reynaud, D., Collet, C., Lemaitre, N., Michy, T., ... & Benharouga, M. (2022). Role of NLRP7 in normal and malignant trophoblast cells. Biomedicines, 10(2), 252.

Slim, R., Fisher, R., Milhavet, F., Hemida, R., Rojas, S., Rittore, C., ... & Touitou, I. (2022). Biallelic NLRP7 variants in patients with recurrent hydatidiform mole: A review and expert consensus. Human Mutation, 43(12), 1732-1744.

Carriere, J., Dorfleutner, A., & Stehlik, C. (2021). NLRP7: From inflammasome regulation to human disease. Immunology, 163(4), 363-376.

Li, B., Qi, Z. P., He, D. L., Chen, Z. H., Liu, J. Y., Wong, M. W., ... & Zhong, Y. S. (2021). NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 40, 1-17.

Reynaud, D., Abi Nahed, R., Lemaitre, N., Bolze, P. A., Traboulsi, W., Sergent, F., ... & Alfaidy, N. (2021). NLRP7 promotes choriocarcinoma growth and progression through the establishment of an immunosuppressive microenvironment. Cancers, 13(12), 2999.

Rezaei, M., Suresh, B., Bereke, E., Hadipour, Z., Aguinaga, M., Qian, J., ... & Slim, R. (2021). Novel pathogenic variants in NLRP7, NLRP5, and PADI6 in patients with recurrent hydatidiform moles and reproductive failure. Clinical Genetics, 99(6), 823-828.

Alici-Garipcan, A., Özçimen, B., Süder, I., Ülker, V., Önder, T. T., & Özören, N. (2020). NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts. Cell Death & Disease, 11(8), 658.

Tsai, P. Y., Chen, K. R., Li, Y. C., & Kuo, P. L. (2019). NLRP7 is involved in the differentiation of the decidual macrophages. International journal of molecular sciences, 20(23), 5994.

Abi Nahed, R., Reynaud, D., Borg, A. J., Traboulsi, W., Wetzel, A., Sapin, V., ... & Alfaidy, N. (2019). NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation. Journal of molecular medicine, 97, 355-367.

Fallahi, J., Razban, V., Momtahan, M., Akbarzadeh-Jahromi, M., Namavar-Jahromi, B., Anvar, Z., & Fardaei, M. (2019). A novel mutation in NLRP7 related to recurrent hydatidiform mole and reproductive failure. International journal of fertility & sterility, 13(2), 135.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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