Mouse Anti-NLRP7 Recombinant Antibody (CBWJN-0161) (CBMAB-N2709-WJ)

Name: Mouse Anti-NLRP7 Recombinant Antibody (CBWJN-0161)
SKU: CBMAB-N2709-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0161

Application

WB, IP

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NLR Family Pyrin Domain Containing 7

Introduction

This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Entrez Gene ID

199713

UniProt ID

Q8WX94

Alternative Names

NLR Family Pyrin Domain Containing 7; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 7; Nucleotide-Binding Oligomerization Domain Protein 12; NACHT, Leucine Rich Repeat And PYD Containing 7; PYPAF3; NALP7; NOD12; NACHT, LRR And PYD Domains-Containing Protein 7;

Function

Inhibits CASP1/caspase-1-dependent IL1B secretion.

Biological Process

Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of aspartic-type peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein processingManual Assertion Based On ExperimentIDA:UniProtKB

Abi Nahed, R., Elkhoury Mikhael, M., Reynaud, D., Collet, C., Lemaitre, N., Michy, T., ... & Benharouga, M. (2022). Role of NLRP7 in normal and malignant trophoblast cells. Biomedicines, 10(2), 252.

Slim, R., Fisher, R., Milhavet, F., Hemida, R., Rojas, S., Rittore, C., ... & Touitou, I. (2022). Biallelic NLRP7 variants in patients with recurrent hydatidiform mole: A review and expert consensus. Human Mutation, 43(12), 1732-1744.

Carriere, J., Dorfleutner, A., & Stehlik, C. (2021). NLRP7: From inflammasome regulation to human disease. Immunology, 163(4), 363-376.

Li, B., Qi, Z. P., He, D. L., Chen, Z. H., Liu, J. Y., Wong, M. W., ... & Zhong, Y. S. (2021). NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 40, 1-17.

Reynaud, D., Abi Nahed, R., Lemaitre, N., Bolze, P. A., Traboulsi, W., Sergent, F., ... & Alfaidy, N. (2021). NLRP7 promotes choriocarcinoma growth and progression through the establishment of an immunosuppressive microenvironment. Cancers, 13(12), 2999.

Rezaei, M., Suresh, B., Bereke, E., Hadipour, Z., Aguinaga, M., Qian, J., ... & Slim, R. (2021). Novel pathogenic variants in NLRP7, NLRP5, and PADI6 in patients with recurrent hydatidiform moles and reproductive failure. Clinical Genetics, 99(6), 823-828.

Alici-Garipcan, A., Özçimen, B., Süder, I., Ülker, V., Önder, T. T., & Özören, N. (2020). NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts. Cell Death & Disease, 11(8), 658.

Tsai, P. Y., Chen, K. R., Li, Y. C., & Kuo, P. L. (2019). NLRP7 is involved in the differentiation of the decidual macrophages. International journal of molecular sciences, 20(23), 5994.

Abi Nahed, R., Reynaud, D., Borg, A. J., Traboulsi, W., Wetzel, A., Sapin, V., ... & Alfaidy, N. (2019). NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation. Journal of molecular medicine, 97, 355-367.

Fallahi, J., Razban, V., Momtahan, M., Akbarzadeh-Jahromi, M., Namavar-Jahromi, B., Anvar, Z., & Fardaei, M. (2019). A novel mutation in NLRP7 related to recurrent hydatidiform mole and reproductive failure. International journal of fertility & sterility, 13(2), 135.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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