NLRP7

This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Full Name

NLR Family Pyrin Domain Containing 7

Function

Inhibits CASP1/caspase-1-dependent IL1B secretion.

Biological Process

Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of aspartic-type peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein processingManual Assertion Based On ExperimentIDA:UniProtKB