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Rabbit Anti-NLRX1 Recombinant Antibody (D4M3Z) (CBMAB-N2711-WJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D4M3Z
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR Family Member X1
Introduction
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Entrez Gene ID
Human79671
Mouse270151
Rat315599
UniProt ID
HumanQ86UT6
MouseQ3TL44
RatQ5FVQ8
Alternative Names
NLR Family Member X1; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing X1; Nucleotide-Binding Oligomerization Domain Protein 26; Nucleotide-Binding Oligomerization Domain Protein 5; Nucleotide-Binding Oligomerization Domain Protein 9; Caterpiller Protein 11.3; NOD-Like Receptor X1;
Function
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010).
Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352).
Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910).
Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
Biological Process
Innate immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of innate immune responseIEA:Ensembl
Negative regulation of interferon-beta productionIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of RIG-I signaling pathwayIEA:Ensembl
Cellular Location
Mitochondrion outer membrane
More Infomation

Bi, P. Y., Killackey, S. A., Schweizer, L., & Girardin, S. E. (2023). NLRX1: versatile functions of a mitochondrial NLR protein that controls mitophagy. Biomedical Journal, 100635.

Pickering, R. J., & Booty, L. M. (2021). NLR in eXile: Emerging roles of NLRX1 in immunity and human disease. Immunology, 162(3), 268-280.

Fekete, T., Bencze, D., Bíró, E., Benkő, S., & Pázmándi, K. (2021). Focusing on the cell type specific regulatory actions of NLRX1. International journal of molecular sciences, 22(3), 1316.

Kastelberg, B., Tubau-Juni, N., Ayubi, T., Leung, A., Leber, A., Hontecillas, R., ... & Kale, S. D. (2020). NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis. PLoS Pathogens, 16(9), e1008854.

Luo, X., Donnelly, C. R., Gong, W., Heath, B. R., Hao, Y., Donnelly, L. A., ... & Lei, Y. L. (2020). HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. The Journal of clinical investigation, 130(4), 1635-1652.

Zhang, H., Xiao, Y., Nederlof, R., Bakker, D., Zhang, P., Girardin, S. E., ... & Zuurbier, C. J. (2020). NLRX1 deletion increases ischemia-reperfusion damage and activates glucose metabolism in mouse heart. Frontiers in immunology, 11, 591815.

Chu, X., Wu, S., & Raju, R. (2019). NLRX1 regulation following acute mitochondrial injury. Frontiers in immunology, 10, 2431.

Nagai-Singer, M. A., Morrison, H. A., & Allen, I. C. (2019). NLRX1 is a multifaceted and enigmatic regulator of immune system function. Frontiers in Immunology, 10, 2419.

Ma, D., Zhao, Y., She, J., Zhu, Y., Zhao, Y., Liu, L., & Zhang, Y. (2019). NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling. International Immunopharmacology, 71, 7-13.

Gharagozloo, M., Mahmoud, S., Simard, C., Yamamoto, K., Bobbala, D., Ilangumaran, S., ... & Gris, D. (2019). NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. PLoS biology, 17(9), e3000451.

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For research use only. Not intended for any clinical use.

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