Rabbit Anti-NLRX1 Recombinant Antibody (D4M3Z) (CBMAB-N2711-WJ)

Name: Rabbit Anti-NLRX1 Recombinant Antibody (D4M3Z)
SKU: CBMAB-N2711-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D4M3Z

Application

WB, IP

Specificity

Human, Mouse, Rat

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NLR Family Member X1

Introduction

The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

Entrez Gene ID

Human	79671
Mouse	270151
Rat	315599

UniProt ID

Human	Q86UT6
Mouse	Q3TL44
Rat	Q5FVQ8

Alternative Names

NLR Family Member X1; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing X1; Nucleotide-Binding Oligomerization Domain Protein 26; Nucleotide-Binding Oligomerization Domain Protein 5; Nucleotide-Binding Oligomerization Domain Protein 9; Caterpiller Protein 11.3; NOD-Like Receptor X1;

Function

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010).
Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352).
Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910).
Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Biological Process

Innate immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of innate immune responseIEA:Ensembl
Negative regulation of interferon-beta productionIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of RIG-I signaling pathwayIEA:Ensembl

Cellular Location

Mitochondrion outer membrane

Bi, P. Y., Killackey, S. A., Schweizer, L., & Girardin, S. E. (2023). NLRX1: versatile functions of a mitochondrial NLR protein that controls mitophagy. Biomedical Journal, 100635.

Pickering, R. J., & Booty, L. M. (2021). NLR in eXile: Emerging roles of NLRX1 in immunity and human disease. Immunology, 162(3), 268-280.

Fekete, T., Bencze, D., Bíró, E., Benkő, S., & Pázmándi, K. (2021). Focusing on the cell type specific regulatory actions of NLRX1. International journal of molecular sciences, 22(3), 1316.

Kastelberg, B., Tubau-Juni, N., Ayubi, T., Leung, A., Leber, A., Hontecillas, R., ... & Kale, S. D. (2020). NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis. PLoS Pathogens, 16(9), e1008854.

Luo, X., Donnelly, C. R., Gong, W., Heath, B. R., Hao, Y., Donnelly, L. A., ... & Lei, Y. L. (2020). HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. The Journal of clinical investigation, 130(4), 1635-1652.

Zhang, H., Xiao, Y., Nederlof, R., Bakker, D., Zhang, P., Girardin, S. E., ... & Zuurbier, C. J. (2020). NLRX1 deletion increases ischemia-reperfusion damage and activates glucose metabolism in mouse heart. Frontiers in immunology, 11, 591815.

Chu, X., Wu, S., & Raju, R. (2019). NLRX1 regulation following acute mitochondrial injury. Frontiers in immunology, 10, 2431.

Nagai-Singer, M. A., Morrison, H. A., & Allen, I. C. (2019). NLRX1 is a multifaceted and enigmatic regulator of immune system function. Frontiers in Immunology, 10, 2419.

Ma, D., Zhao, Y., She, J., Zhu, Y., Zhao, Y., Liu, L., & Zhang, Y. (2019). NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling. International Immunopharmacology, 71, 7-13.

Gharagozloo, M., Mahmoud, S., Simard, C., Yamamoto, K., Bobbala, D., Ilangumaran, S., ... & Gris, D. (2019). NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. PLoS biology, 17(9), e3000451.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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