Mouse Anti-NME5 Recombinant Antibody (4F5) (CBMAB-N2795-WJ)

Name: Mouse Anti-NME5 Recombinant Antibody (4F5)
SKU: CBMAB-N2795-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F5

Application

ELISA, IP, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

Introduction

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

Entrez Gene ID

8382

UniProt ID

P56597

Alternative Names

NME/NM23 Family Member 5; Non-Metastatic Cells 5, Protein Expressed In (Nucleoside-Diphosphate Kinase); Inhibitor Of P53-Induced Apoptosis-Beta; Testis-Specific Nm23 Homolog; NDP Kinase Homolog 5; IPIA-Beta; NDK-H 5; NM23-H5;

Function

Biological Process

Cilium assemblyIEA:Ensembl
CTP biosynthetic processIEA:InterPro
Epithelial cilium movement involved in extracellular fluid movementIEA:Ensembl
GTP biosynthetic processIEA:InterPro
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Nucleoside metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Spermatid developmentISS:UniProtKB
SpermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
UTP biosynthetic processIEA:InterPro
Ventricular system developmentIEA:Ensembl

Cellular Location

Cell projection, cilium

Adam, K., Ning, J., Reina, J., & Hunter, T. (2020). NME/NM23/NDPK and histidine phosphorylation. International journal of molecular sciences, 21(16), 5848.

Cho, E. H., Huh, H. J., Jeong, I., Lee, N. Y., Koh, W. J., Park, H. C., & Ki, C. S. (2020). A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects. Clinical genetics, 98(1), 64-68.

Perina, D., Korolija, M., Mikoč, A., Halasz, M., Herak Bosnar, M., & Ćetković, H. (2019). Characterization of Nme5-like gene/protein from the red alga Chondrus crispus. Marine drugs, 18(1), 13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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