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Mouse Anti-NME8 Recombinant Antibody (CBYJT-1504) (CBMAB-T0538-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to NME8 (NME/NM23 Family Member 8). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all NME8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1504
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa530-587 from human TXNDC3 (NP_057700) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 530-587

Target

Full Name
NME/NM23 Family Member 8
Introduction
NME8 is a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of NME8 encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in NME8 are implicated in primary ciliary dyskinesia type 6.
Entrez Gene ID
51314
UniProt ID
Q8N427
Alternative Names
NME/NM23 Family Member 8; Thioredoxin Domain Containing 3 (Spermatozoa); Spermatid-Specific Thioredoxin-2; Sperm-Specific Thioredoxin 2; Sptrx-2; NM23-H8; TXNDC3; SPTRX2
Function
Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cellular response to reactive oxygen speciesIEA:Ensembl
Cilium assemblyManual Assertion Based On ExperimentIMP:SYSCILIA_CCNET
Flagellated sperm motilityIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Involvement in disease
Ciliary dyskinesia, primary, 6 (CILD6):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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