NME8

NME8 is a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of NME8 encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in NME8 are implicated in primary ciliary dyskinesia type 6.

Full Name

NME/NM23 Family Member 8

Function

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cellular response to reactive oxygen speciesIEA:Ensembl
Cilium assemblyManual Assertion Based On ExperimentIMP:SYSCILIA_CCNET
Flagellated sperm motilityIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW

Cellular Location

Cytoplasm

Involvement in disease

Ciliary dyskinesia, primary, 6 (CILD6):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.