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Mouse Anti-NMUR2 Recombinant Antibody (2A2) (CBMAB-N2835-WJ)

This product is a Mouse antibody that recognizes NMUR2. The antibody 2A2 can be used for immunoassay techniques such as: IHC-P.
See all NMUR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A2
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.4 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuromedin U Receptor 2
Introduction
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
Entrez Gene ID
56923
UniProt ID
Q9GZQ4
Alternative Names
Neuromedin U Receptor 2; G-Protein Coupled Receptor TGR-1; G-Protein Coupled Receptor FM-4; NMU-R2; NMU2R; TGR1;
Function
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Biological Process
Activation of phospholipase A2 activity by calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Arachidonic acid secretionManual Assertion Based On ExperimentIDA:UniProtKB
Calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Calcium-mediated signaling1 PublicationNAS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system developmentManual Assertion Based On ExperimentIEP:UniProtKB
Feeding behaviorManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Grooming behaviorIEA:Ensembl
Inositol phosphate-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIDA:UniProtKB
Reduction of food intake in response to dietary excessIEA:Ensembl
Regulation of sensory perception of painIEA:Ensembl
Regulation of smooth muscle contraction1 PublicationNAS:UniProtKB
Response to painIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-49
Helical: 50-70
Cytoplasmic: 71-82
Helical: 83-103
Extracellular: 104-123
Helical: 124-146
Cytoplasmic: 147-165
Helical: 166-186
Extracellular: 187-214
Helical: 215-235
Cytoplasmic: 236-265
Helical: 266-286
Extracellular: 287-301
Helical: 302-322
Cytoplasmic: 323-415

Yadav, K., Yadav, A., Rajpoot, A., & Mishra, R. K. (2023). Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis. Peptides, 159, 170899.

Cao, Y., Lv, Q., Huang, Z., & Li, Y. (2023). Astragaloside-IV induces the differentiation of bone marrow mesenchymal stem cells into osteoblasts through NMUR2-mediated Wnt/β-catenin pathway. Regenerative Medicine, (0).

Sun, X., Zeng, C., Wang, F., Zhang, Z., Yang, F., Liu, Z. P., ... & Zhang, G. M. (2022). Neuromedin S regulates steroidogenesis through maintaining mitochondrial morphology and function via NMUR2 in goat ovarian granulosa cells. International Journal of Molecular Sciences, 23(21), 13402.

Do, A. R., An, J., Jo, J., Kim, W. J., Kang, H. Y., Lee, S., ... & Kim, T. B. (2022). A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD. Scientific Reports, 12(1), 22073.

Piwowarczyk-Nowak, A., Pałasz, A., Suszka-Świtek, A., Błaszczyk, I., Bogus, K., Łasut-Szyszka, B., ... & Worthington, J. J. (2022). Effect of Escitalopram on the Number of DCX-Positive Cells and NMUR2 Receptor Expression in the Rat Hippocampus under the Condition of NPSR Receptor Blockade. Pharmaceuticals, 15(5), 631.

Przygodzka, P., Sochacka, E., Soboska, K., Pacholczyk, M., Papiewska-Pająk, I., Przygodzki, T., ... & Boncela, J. (2021). Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor. Journal of Experimental & Clinical Cancer Research, 40(1), 1-17.

Peng, S., Lu, Y., Li, P., Liu, P., Shi, X., Liu, C., ... & Wang, J. (2019). The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways. Biochemical and biophysical research communications, 512(3), 616-622.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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