NMUR2

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

Full Name

Neuromedin U Receptor 2

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Biological Process

Activation of phospholipase A2 activity by calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Arachidonic acid secretionManual Assertion Based On ExperimentIDA:UniProtKB
Calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Calcium-mediated signaling1 PublicationNAS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system developmentManual Assertion Based On ExperimentIEP:UniProtKB
Feeding behaviorManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Grooming behaviorIEA:Ensembl
Inositol phosphate-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIDA:UniProtKB
Reduction of food intake in response to dietary excessIEA:Ensembl
Regulation of sensory perception of painIEA:Ensembl
Regulation of smooth muscle contraction1 PublicationNAS:UniProtKB
Response to painIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-49
Helical: 50-70
Cytoplasmic: 71-82
Helical: 83-103
Extracellular: 104-123
Helical: 124-146
Cytoplasmic: 147-165
Helical: 166-186
Extracellular: 187-214
Helical: 215-235
Cytoplasmic: 236-265
Helical: 266-286
Extracellular: 287-301
Helical: 302-322
Cytoplasmic: 323-415