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Mouse Anti-NPAS1 Recombinant Antibody (1C9) (CBMAB-N3093-WJ)

This product is a Mouse antibody that recognizes NPAS1. The antibody 1C9 can be used for immunoassay techniques such as: WB, IHC .
See all NPAS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C9
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1.00 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuronal PAS Domain Protein 1
Introduction
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4861
UniProt ID
Q99742
Alternative Names
Neuronal PAS Domain Protein 1; Neuronal PAS1; Class E Basic Helix-Loop-Helix Protein 11; Basic-Helix-Loop-Helix-PAS Protein MOP5; PAS Domain-Containing Protein 5; Member Of PAS Superfamily 5;
Function
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity).
Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity).
Biological Process
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Maternal behaviorIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Startle responseIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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