Mouse Anti-NPAS1 Recombinant Antibody (5B2) (CBMAB-N3095-WJ)

Name: Mouse Anti-NPAS1 Recombinant Antibody (5B2)
SKU: CBMAB-N3095-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5B2

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1.00 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuronal PAS Domain Protein 1

Introduction

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]

Entrez Gene ID

4861

UniProt ID

Q99742

Alternative Names

Neuronal PAS Domain Protein 1; Neuronal PAS1; Class E Basic Helix-Loop-Helix Protein 11; Basic-Helix-Loop-Helix-PAS Protein MOP5; PAS Domain-Containing Protein 5; Member Of PAS Superfamily 5;

Function

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity).
Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity).

Biological Process

Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Maternal behaviorIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Startle responseIEA:Ensembl

Cellular Location

Nucleus

Morais-Silva, G., Campbell, R. R., Nam, H., Basu, M., Pagliusi, M., Fox, M. E., ... & Lobo, M. K. (2023). Molecular, circuit, and stress response characterization of Ventral Pallidum Npas1-neurons. Journal of Neuroscience, 43(3), 405-418.

Morais-Silva, G., Nam, H., Campbell, R., Basu, M., Pagliusi Jr, M., Fox, M. E., ... & Lobo, M. K. (2021). Activation of Npas1-neurons in the Ventral Pallidum Mediates Stress Susceptibility. bioRxiv, 2021-10.

Chen, P. Y., Tsai, Y. W., Cheng, Y. J., Giangrande, A., & Chien, C. T. (2019). Glial response to hypoxia in mutants of NPAS1/3 homolog Trachealess through Wg signaling to modulate synaptic bouton organization. PLoS genetics, 15(8), e1007980.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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