Mouse Anti-NPM3 Recombinant Antibody (CBT2632) (V2LY-0625-LY1995)

Name: Mouse Anti-NPM3 Recombinant Antibody (CBT2632)
SKU: V2LY-0625-LY1995
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse

Clone

CBT2632

Antibody Isotype

IgG1

Application

IHC, FC

Basic Information

Immunogen

Purified recombinant fragment of human NPM3 (AA: full 1-178) expressed in E. Coli.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

nucleophosmin/nucleoplasmin, 3

Entrez Gene ID

10360

UniProt ID

O75607

Function

Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534).
Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753).
Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447).

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
rRNA processingIEA:Ensembl
rRNA transcriptionIEA:Ensembl

Cellular Location

Nucleus
Nucleus, nucleolus
Mainly found in the granular component of the nucleolus.

PTM

Phosphorylated.

More Infomation

References

Wang, H., Zhou, Z., Zhang, J., Hao, T., Wang, P., Wu, P., ... & Yin, S. (2024). Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer. Cancer Letters, 581, 216498.

Wei, Q., Zhou, J., Wang, X., Li, Z., Chen, X., Chen, K., & Jiang, R. (2023). Pan-cancer analysis of the prognostic and immunological role of nucleophosmin/nucleoplasmin 3 (NPM3) and its potential significance in lung adenocarcinoma. Cancer Pathogenesis and Therapy, 1(04), 238-252.

López, D. J., Rodríguez, J. A., & Bañuelos, S. (2020). Nucleophosmin, a multifunctional nucleolar organizer with a role in DNA repair. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1868(12), 140532.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-NPM3 Recombinant Antibody (CBT3758)

Mouse Anti-NPM3 Recombinant Antibody (3F2)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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