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NPM3

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq]
Full Name
nucleophosmin/nucleoplasmin, 3
Function
Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534).
Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753).
Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447).
Biological Process
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
rRNA processingIEA:Ensembl
rRNA transcriptionIEA:Ensembl
Cellular Location
Nucleus
Nucleus, nucleolus
Mainly found in the granular component of the nucleolus.
PTM
Phosphorylated.
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Anti-NPM3 antibodies

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Mouse Anti-NPM3 Recombinant Antibody (3F2) (CBMAB-N3163-WJ)

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Target: NPM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F2
Application*: E, WB
Datasheet SDS

Mouse Anti-NPM3 Recombinant Antibody (CBT3758) (V2LY-0625-LY1996)

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Target: NPM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3758
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-NPM3 Recombinant Antibody (CBT2632) (V2LY-0625-LY1995)

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Target: NPM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT2632
Application*: IH, F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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