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Mouse Anti-NPR2 Recombinant Antibody (2A6) (CBMAB-N3242-WJ)

This product is a Mouse antibody that recognizes NPR2. The antibody 2A6 can be used for immunoassay techniques such as: ELISA, WB, IHC.
See all NPR2 antibodies
Published Data
Fig. 1 Immunohistochemistry
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A6
Antibody Isotype
IgG2b, κ
Application
ELISA, WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Introduction
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4882
UniProt ID
P20594
Alternative Names
Natriuretic Peptide Receptor 2; Atrial Natriuretic Peptide Receptor Type B; Guanylate Cyclase 2B; Guanylate Cyclase B; EC 4.6.1.2; ANPR-B; ANPRB; ANP-B; NPR-B; GC-B; Natriuretic Peptide Receptor B/Guanylate Cyclase B (Atrionatriuretic Peptide Receptor B); Atrial Natriuretic Peptide B-Type Receptor; Acromesomelic Dysplasia, Maroteaux Type;
Function
Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Biological Process
Bone developmentIEA:Ensembl
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIEP:UniProtKB
cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Negative regulation of meiotic cell cycleIEA:Ensembl
Negative regulation of oocyte maturationIEA:Ensembl
OssificationIEA:UniProtKB-KW
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of blood pressureManual Assertion Based On ExperimentTAS:ProtInc
Reproductive processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Acromesomelic dysplasia 1 (AMD1):
A form of acromesomelic dysplasia, a skeletal disorder characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMD1 is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. All skeletal elements are present but show abnormal rates of linear growth.
Epiphyseal chondrodysplasia, Miura type (ECDM):
An overgrowth syndrome characterized by tall stature, long hands and feet with arachnodactyly, macrodactyly of the great toes, scoliosis, coxa valga and slipped capital femoral epiphysis.
Short stature with non-specific skeletal abnormalities (SNSK):
A condition characterized by short stature, defined as a height less than 2 SD below normal, and no endocrine abnormalities.
Topology
Extracellular: 23-458
Helical: 459-478
Cytoplasmic: 479-1047
PTM
Phosphorylated (PubMed:26980729).
Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity).
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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