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Mouse Anti-NPY1R Recombinant Antibody (CBWJN-1018) (CBMAB-N0505-WJ)

This product is a Mouse antibody that recognizes NPY1R. The antibody CBWJN-1018 can be used for immunoassay techniques such as: FC, CyTOF.
See all NPY1R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1018
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neuropeptide Y receptor Y1
Introduction
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Entrez Gene ID
4886
UniProt ID
P25929
Alternative Names
Neuropeptide Y Receptor Y1; NPY1-R; NPYR; Neuropeptide Y Receptor Type 1; NPYY1;
Function
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY> [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY> NPY (2-36)> [Ile-31, Gln-34] PP and PYY (3-36)> PP> NPY free acid.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Feeding behaviorIEA:Ensembl
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Glucose metabolic processIEA:Ensembl
Locomotory behaviorIEA:Ensembl
Outflow tract morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of blood pressureIEA:Ensembl
Regulation of multicellular organism growthIEA:Ensembl
Sensory perception of painIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-44
Helical: 45-65
Cytoplasmic: 66-76
Helical: 77-97
Extracellular: 98-116
Helical: 117-137
Cytoplasmic: 138-154
Helical: 155-175
Extracellular: 176-211
Helical: 212-232
Cytoplasmic: 233-260
Helical: 261-281
Extracellular: 282-299
Helical: 300-320
Cytoplasmic: 321-384

Nelson, T. S., Allen, H. N., Basu, P., Prasoon, P., Nguyen, E., Arokiaraj, C. M., ... & Taylor, B. K. (2023). Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp. JCI insight, 8(22).

Niranjan, V., Philip, S., Uttarkar, A., Kusanur, R., & Kumar, J. (2023). Design of novel imidazopyrazine derivative against breast cancer via targeted NPY1R antagonist. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 23(15), 1783-1793.

Bhat, R., Thangavel, H., Abdulkareem, N. M., Vasaikar, S., De Angelis, C., Bae, L., ... & Trivedi, M. V. (2022). NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer. Scientific Reports, 12(1), 1972.

Lafferty, R. A., Tanday, N., Flatt, P. R., & Irwin, N. (2020). Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction. Biochimica et Biophysica Acta (BBA)-General Subjects, 1864(5), 129543.

Wittrisch, S., Klöting, N., Mörl, K., Chakaroun, R., Blüher, M., & Beck-Sickinger, A. G. (2020). NPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression. Molecular Metabolism, 31, 163-180.

Bertocchi, I., Oberto, A., Longo, A., Palanza, P., & Eva, C. (2020). Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions. Hormones and behavior, 125, 104824.

Franco, L. O., Carvalho, M. J., Costa, J., Ferreira, P. A., Guedes, J. R., Sousa, R., ... & Peça, J. (2020). Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling. Neuropsychopharmacology, 45(9), 1438-1447.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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