NPY1R

Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle (Herzog et al., 1992 [PubMed 1321422]).[supplied by OMIM

Full Name

neuropeptide Y receptor Y1

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY> [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY> NPY (2-36)> [Ile-31, Gln-34] PP and PYY (3-36)> PP> NPY free acid.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Feeding behaviorIEA:Ensembl
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Glucose metabolic processIEA:Ensembl
Locomotory behaviorIEA:Ensembl
Outflow tract morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of blood pressureIEA:Ensembl
Regulation of multicellular organism growthIEA:Ensembl
Sensory perception of painIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-44
Helical: 45-65
Cytoplasmic: 66-76
Helical: 77-97
Extracellular: 98-116
Helical: 117-137
Cytoplasmic: 138-154
Helical: 155-175
Extracellular: 176-211
Helical: 212-232
Cytoplasmic: 233-260
Helical: 261-281
Extracellular: 282-299
Helical: 300-320
Cytoplasmic: 321-384